diff --git a/llvm/lib/Passes/PassBuilder.cpp b/llvm/lib/Passes/PassBuilder.cpp
--- a/llvm/lib/Passes/PassBuilder.cpp
+++ b/llvm/lib/Passes/PassBuilder.cpp
@@ -1650,6 +1650,11 @@
   // Convert @llvm.global.annotations to !annotation metadata.
   MPM.addPass(Annotation2MetadataPass());
 
+  // Create a function that performs CFI checks for cross-DSO calls with targets
+  // in the current module.  (Note: Add this passs irrespective of the
+  // optimization level).
+  MPM.addPass(CrossDSOCFIPass());
+
   if (Level == OptimizationLevel::O0) {
     // The WPD and LowerTypeTest passes need to run at -O0 to lower type
     // metadata and intrinsics.
@@ -1868,10 +1873,6 @@
   MainFPM.addPass(JumpThreadingPass(/*InsertFreezeWhenUnfoldingSelect*/ true));
   MPM.addPass(createModuleToFunctionPassAdaptor(std::move(MainFPM)));
 
-  // Create a function that performs CFI checks for cross-DSO calls with
-  // targets in the current module.
-  MPM.addPass(CrossDSOCFIPass());
-
   // Lower type metadata and the type.test intrinsic. This pass supports
   // clang's control flow integrity mechanisms (-fsanitize=cfi*) and needs
   // to be run at link time if CFI is enabled. This pass does nothing if
diff --git a/llvm/test/Other/new-pm-O0-defaults.ll b/llvm/test/Other/new-pm-O0-defaults.ll
--- a/llvm/test/Other/new-pm-O0-defaults.ll
+++ b/llvm/test/Other/new-pm-O0-defaults.ll
@@ -38,6 +38,7 @@
 ; CHECK-THINLTO-NEXT: Running pass: EliminateAvailableExternallyPass
 ; CHECK-THINLTO-NEXT: Running pass: GlobalDCEPass
 ; CHECK-LTO: Running pass: Annotation2MetadataPass
+; CHECK-LTO: Running pass: CrossDSOCFIPass on [module]
 ; CHECK-LTO-NEXT: Running pass: WholeProgramDevirtPass
 ; CHECK-LTO-NEXT: Running analysis: InnerAnalysisManagerProxy
 ; CHECK-LTO-NEXT: Running pass: LowerTypeTestsPass
diff --git a/llvm/test/Other/new-pm-lto-defaults.ll b/llvm/test/Other/new-pm-lto-defaults.ll
--- a/llvm/test/Other/new-pm-lto-defaults.ll
+++ b/llvm/test/Other/new-pm-lto-defaults.ll
@@ -26,6 +26,7 @@
 ; RUN:     --check-prefix=CHECK-O3 --check-prefix=CHECK-EP-Peephole
 
 ; CHECK-O: Running pass: Annotation2Metadata
+; CHECK-O-NEXT: Running pass: CrossDSOCFIPass
 ; CHECK-O-NEXT: Running pass: GlobalDCEPass
 ; CHECK-O-NEXT: Running pass: ForceFunctionAttrsPass
 ; CHECK-O-NEXT: Running pass: InferFunctionAttrsPass
@@ -123,7 +124,6 @@
 ; CHECK-O23SZ-NEXT: Running pass: InstCombinePass on foo
 ; CHECK-EP-Peephole-NEXT: Running pass: NoOpFunctionPass on foo
 ; CHECK-O23SZ-NEXT: Running pass: JumpThreadingPass on foo
-; CHECK-O23SZ-NEXT: Running pass: CrossDSOCFIPass
 ; CHECK-O23SZ-NEXT: Running pass: LowerTypeTestsPass
 ; CHECK-O-NEXT: Running pass: LowerTypeTestsPass
 ; CHECK-O23SZ-NEXT: Running pass: SimplifyCFGPass