diff --git a/compiler-rt/lib/tsan/rtl/tsan_interceptors_posix.cpp b/compiler-rt/lib/tsan/rtl/tsan_interceptors_posix.cpp
--- a/compiler-rt/lib/tsan/rtl/tsan_interceptors_posix.cpp
+++ b/compiler-rt/lib/tsan/rtl/tsan_interceptors_posix.cpp
@@ -434,6 +434,9 @@
 
     // Ensure thread-safety.
     BlockingMutexLock l(&interceptor_ctx()->atexit_mu);
+    // __cxa_atexit calls calloc. If we don't ignore interceptors, we will fail
+    // due to atexit_mu held on exit from the calloc interceptor.
+    ScopedIgnoreInterceptors ignore;
 
     res = REAL(__cxa_atexit)((void (*)(void *a))at_exit_wrapper, 0, 0);
     // Push AtExitCtx on the top of the stack of callback functions
diff --git a/compiler-rt/lib/tsan/tests/unit/tsan_sync_test.cpp b/compiler-rt/lib/tsan/tests/unit/tsan_sync_test.cpp
--- a/compiler-rt/lib/tsan/tests/unit/tsan_sync_test.cpp
+++ b/compiler-rt/lib/tsan/tests/unit/tsan_sync_test.cpp
@@ -48,6 +48,9 @@
 }
 
 TEST(MetaMap, Sync) {
+  // EXPECT can call memset/etc. Disable interceptors to prevent
+  // them from detecting that we exit runtime with mutexes held.
+  ScopedIgnoreInterceptors ignore;
   ThreadState *thr = cur_thread();
   MetaMap *m = &ctx->metamap;
   u64 block[4] = {};  // fake malloc block
@@ -71,6 +74,7 @@
 }
 
 TEST(MetaMap, MoveMemory) {
+  ScopedIgnoreInterceptors ignore;
   ThreadState *thr = cur_thread();
   MetaMap *m = &ctx->metamap;
   u64 block1[4] = {};  // fake malloc block
@@ -108,6 +112,7 @@
 }
 
 TEST(MetaMap, ResetSync) {
+  ScopedIgnoreInterceptors ignore;
   ThreadState *thr = cur_thread();
   MetaMap *m = &ctx->metamap;
   u64 block[1] = {};  // fake malloc block