Index: lib/Driver/ToolChains.cpp
===================================================================
--- lib/Driver/ToolChains.cpp
+++ lib/Driver/ToolChains.cpp
@@ -3654,6 +3654,8 @@
   const bool IsX86_64 = getTriple().getArch() == llvm::Triple::x86_64;
   const bool IsMIPS64 = getTriple().getArch() == llvm::Triple::mips64 ||
                         getTriple().getArch() == llvm::Triple::mips64el;
+  const bool IsPowerPC64 = getTriple().getArch() == llvm::Triple::ppc64 ||
+                           getTriple().getArch() == llvm::Triple::ppc64le;
   SanitizerMask Res = ToolChain::getSupportedSanitizers();
   Res |= SanitizerKind::Address;
   Res |= SanitizerKind::KernelAddress;
@@ -3661,9 +3663,10 @@
   if (IsX86_64 || IsMIPS64) {
     Res |= SanitizerKind::DataFlow;
     Res |= SanitizerKind::Leak;
-    Res |= SanitizerKind::Memory;
     Res |= SanitizerKind::Thread;
   }
+  if (IsX86_64 || IsMIPS64 || IsPowerPC64)
+    Res |= SanitizerKind::Memory;
   if (IsX86 || IsX86_64) {
     Res |= SanitizerKind::Function;
     Res |= SanitizerKind::SafeStack;
Index: test/Driver/msan.c
===================================================================
--- /dev/null
+++ test/Driver/msan.c
@@ -0,0 +1,12 @@
+// RUN: %clang     -target x86_64-unknown-linux -fsanitize=memory %s -S -emit-llvm -o - | FileCheck %s
+// RUN: %clang -O1 -target x86_64-unknown-linux -fsanitize=memory %s -S -emit-llvm -o - | FileCheck %s
+// RUN: %clang -O2 -target x86_64-unknown-linux -fsanitize=memory %s -S -emit-llvm -o - | FileCheck %s
+// RUN: %clang -O3 -target x86_64-unknown-linux -fsanitize=memory %s -S -emit-llvm -o - | FileCheck %s
+// RUN: %clang -target mips64-linux-gnu -fsanitize=memory %s -S -emit-llvm -o - | FileCheck %s
+// RUN: %clang -target mips64el-unknown-linux-gnu -fsanitize=memory %s -S -emit-llvm -o - | FileCheck %s
+// RUN: %clang -target powerpc64-unknown-linux-gnu -fsanitize=memory %s -S -emit-llvm -o - | FileCheck %s
+// RUN: %clang -target powerpc64le-unknown-linux-gnu -fsanitize=memory %s -S -emit-llvm -o - | FileCheck %s
+// Verify that -fsanitize=memory invokes msan instrumentation.
+
+int foo(int *a) { return *a; }
+// CHECK: __msan_init