diff --git a/clang/lib/StaticAnalyzer/Core/SValBuilder.cpp b/clang/lib/StaticAnalyzer/Core/SValBuilder.cpp
--- a/clang/lib/StaticAnalyzer/Core/SValBuilder.cpp
+++ b/clang/lib/StaticAnalyzer/Core/SValBuilder.cpp
@@ -712,9 +712,23 @@
           // symbols to use, only content metadata.
           return nonloc::SymbolVal(SymMgr.getExtentSymbol(FTR));
 
-    if (const SymbolicRegion *SymR = R->getSymbolicBase())
-      return makeNonLoc(SymR->getSymbol(), BO_NE,
-                        BasicVals.getZeroWithPtrWidth(), CastTy);
+    if (const SymbolicRegion *SymR = R->getSymbolicBase()) {
+      SymbolRef Sym = SymR->getSymbol();
+      QualType Ty = Sym->getType();
+      // This change is needed for architectures with varying
+      // pointer widths. See the amdgcn opencl reproducer with
+      // this change as an example: solver-sym-simplification-ptr-bool.cl
+      // FIXME: We could encounter a reference here,
+      //        try returning a concrete 'true' since it might
+      //        be easier on the solver.
+      // FIXME: Cleanup remainder of `getZeroWithPtrWidth ()`
+      //        and `getIntWithPtrWidth()` functions to prevent future
+      //        confusion
+      const llvm::APSInt &Zero = Ty->isReferenceType()
+                                     ? BasicVals.getZeroWithPtrWidth()
+                                     : BasicVals.getZeroWithTypeSize(Ty);
+      return makeNonLoc(Sym, BO_NE, Zero, CastTy);
+    }
     // Non-symbolic memory regions are always true.
     return makeTruthVal(true, CastTy);
   }
diff --git a/clang/test/Analysis/solver-sym-simplification-ptr-bool.cl b/clang/test/Analysis/solver-sym-simplification-ptr-bool.cl
new file mode 100644
--- /dev/null
+++ b/clang/test/Analysis/solver-sym-simplification-ptr-bool.cl
@@ -0,0 +1,30 @@
+// RUN: %clang_analyze_cc1 -triple amdgcn-unknown-unknown -analyze -analyzer-checker=core %s
+
+// expected-no-diagnostics
+
+// This test case covers an issue found in the static analyzer
+// solver where pointer sizes were assumed. Pointer sizes may vary on other
+// architectures. This issue was originally discovered on a downstream,
+// custom target, this assert occurs on the custom target and this one
+// without the fix, and is fixed with this change.
+//
+// The assertion appears to be happening as a result of evaluating the
+// SymIntExpr (reg_$0<int * p>) != 0U in VisitSymIntExpr located in
+// SimpleSValBuilder.cpp. The LHS is evaluated to 32b and the RHS is
+// evaluated to 16b. This eventually leads to the assertion in APInt.h.
+//
+// APInt.h:1151: bool llvm::APInt::operator==(const llvm::APInt &) const: Assertion `BitWidth == RHS.BitWidth && "Comparison requires equal bit widths"'
+// 
+void test1(__attribute__((address_space(256))) int * p) {
+  __attribute__((address_space(256))) int * q = p-1;
+  if (q) {}
+  if (q) {}
+  (void)q;
+}
+ 
+void test2(__attribute__((address_space(256))) int * p) {
+  __attribute__((address_space(256))) int * q = p-1;
+  q && q; 
+  q && q; 
+  (void)q;
+}