diff --git a/llvm/lib/IR/Instructions.cpp b/llvm/lib/IR/Instructions.cpp
--- a/llvm/lib/IR/Instructions.cpp
+++ b/llvm/lib/IR/Instructions.cpp
@@ -45,6 +45,10 @@
 
 using namespace llvm;
 
+static cl::opt<bool> DisableI2pP2iOpt(
+    "disable-i2p-p2i-opt", cl::init(false),
+    cl::desc("Disables inttoptr/ptrtoint roundtrip optimization"));
+
 //===----------------------------------------------------------------------===//
 //                            AllocaInst Class
 //===----------------------------------------------------------------------===//
@@ -2841,6 +2845,9 @@
         return secondOp;
       return 0;
     case 7: {
+      // Disable inttoptr/ptrtoint optimization if enabled.
+      if (DisableI2pP2iOpt)
+        return 0;
       // Cannot simplify if address spaces are different!
       if (SrcTy->getPointerAddressSpace() != DstTy->getPointerAddressSpace())
         return 0;
diff --git a/llvm/test/Transforms/InstCombine/ptr-int-ptr-icmp.ll b/llvm/test/Transforms/InstCombine/ptr-int-ptr-icmp.ll
new file mode 100644
--- /dev/null
+++ b/llvm/test/Transforms/InstCombine/ptr-int-ptr-icmp.ll
@@ -0,0 +1,93 @@
+; NOTE: Assertions have been autogenerated by utils/update_test_checks.py
+; RUN: opt -instcombine -S -disable-i2p-p2i-opt < %s | FileCheck %s
+
+target datalayout = "e-p:64:64-p1:16:16-p2:32:32:32-p3:64:64:64"
+target triple = "x86_64-unknown-linux-gnu"
+
+; icmp (inttoptr (ptrtoint p1)), p2 --> icmp p1, p2.
+
+define i1 @func(i8* %X, i8* %Y) {
+; CHECK-LABEL: @func(
+; CHECK-NEXT:    [[I:%.*]] = ptrtoint i8* [[X:%.*]] to i64
+; CHECK-NEXT:    [[P:%.*]] = inttoptr i64 [[I]] to i8*
+; CHECK-NEXT:    [[CMP:%.*]] = icmp eq i8* [[P]], [[Y:%.*]]
+; CHECK-NEXT:    ret i1 [[CMP]]
+;
+  %i = ptrtoint i8* %X to i64
+  %p = inttoptr i64 %i to i8*
+  %cmp = icmp eq i8* %p, %Y
+  ret i1 %cmp
+}
+
+define i1 @func2(i16* %X, i8* %Y) {
+; CHECK-LABEL: @func2(
+; CHECK-NEXT:    [[I:%.*]] = ptrtoint i16* [[X:%.*]] to i64
+; CHECK-NEXT:    [[P:%.*]] = inttoptr i64 [[I]] to i8*
+; CHECK-NEXT:    [[CMP:%.*]] = icmp eq i8* [[P]], [[Y:%.*]]
+; CHECK-NEXT:    ret i1 [[CMP]]
+;
+  %i = ptrtoint i16* %X to i64
+  %p = inttoptr i64 %i to i8*
+  %cmp = icmp eq i8* %p, %Y
+  ret i1 %cmp
+}
+
+define i1 @func3(i16* %X, i8* %Y) {
+; CHECK-LABEL: @func3(
+; CHECK-NEXT:    [[I:%.*]] = ptrtoint i16* [[X:%.*]] to i64
+; CHECK-NEXT:    [[P:%.*]] = inttoptr i64 [[I]] to i8*
+; CHECK-NEXT:    [[CMP:%.*]] = icmp eq i8* [[P]], [[Y:%.*]]
+; CHECK-NEXT:    ret i1 [[CMP]]
+;
+  %i = ptrtoint i16* %X to i64
+  %p = inttoptr i64 %i to i8*
+  %cmp = icmp eq i8* %Y, %p
+  ret i1 %cmp
+}
+
+; Negative test - Wrong Integer type.
+
+define i1 @func4(i16* %X, i8* %Y) {
+; CHECK-LABEL: @func4(
+; CHECK-NEXT:    [[TMP1:%.*]] = ptrtoint i16* [[X:%.*]] to i64
+; CHECK-NEXT:    [[TMP2:%.*]] = and i64 [[TMP1]], 4294967295
+; CHECK-NEXT:    [[P:%.*]] = inttoptr i64 [[TMP2]] to i8*
+; CHECK-NEXT:    [[CMP:%.*]] = icmp eq i8* [[P]], [[Y:%.*]]
+; CHECK-NEXT:    ret i1 [[CMP]]
+;
+  %i = ptrtoint i16* %X to i32
+  %p = inttoptr i32 %i to i8*
+  %cmp = icmp eq i8* %Y, %p
+  ret i1 %cmp
+}
+
+; Negative test - Pointers in different address space
+
+define i1 @func5(i8* %X, i16 addrspace(3)* %Y){
+; CHECK-LABEL: @func5(
+; CHECK-NEXT:    [[I:%.*]] = ptrtoint i8* [[X:%.*]] to i64
+; CHECK-NEXT:    [[P:%.*]] = inttoptr i64 [[I]] to i16 addrspace(3)*
+; CHECK-NEXT:    [[CMP:%.*]] = icmp eq i16 addrspace(3)* [[P]], [[Y:%.*]]
+; CHECK-NEXT:    ret i1 [[CMP]]
+;
+  %i = ptrtoint i8* %X to i64
+  %p = inttoptr i64 %i to i16 addrspace(3)*
+  %cmp = icmp eq i16 addrspace(3)* %Y, %p
+  ret i1 %cmp
+}
+
+; Negative test - Pointers in different address space
+
+define i1 @func6(i8 addrspace(2)* %X, i16* %Y){
+; CHECK-LABEL: @func6(
+; CHECK-NEXT:    [[TMP1:%.*]] = ptrtoint i8 addrspace(2)* [[X:%.*]] to i32
+; CHECK-NEXT:    [[I:%.*]] = zext i32 [[TMP1]] to i64
+; CHECK-NEXT:    [[P:%.*]] = inttoptr i64 [[I]] to i16*
+; CHECK-NEXT:    [[CMP:%.*]] = icmp eq i16* [[P]], [[Y:%.*]]
+; CHECK-NEXT:    ret i1 [[CMP]]
+;
+  %i = ptrtoint i8 addrspace(2)* %X to i64
+  %p = inttoptr i64 %i to i16*
+  %cmp = icmp eq i16* %Y, %p
+  ret i1 %cmp
+}