diff --git a/llvm/cmake/modules/HandleLLVMOptions.cmake b/llvm/cmake/modules/HandleLLVMOptions.cmake
--- a/llvm/cmake/modules/HandleLLVMOptions.cmake
+++ b/llvm/cmake/modules/HandleLLVMOptions.cmake
@@ -318,8 +318,12 @@
     # Older Clang may support -fno-semantic-interposition but it used local
     # aliases to optimize global variables, which is incompatible with copy
     # relocations due to -fno-pic.
-    if (CMAKE_COMPILER_IS_GNUCXX OR (CMAKE_CXX_COMPILER_ID MATCHES "Clang" AND
-        CMAKE_CXX_COMPILER_VERSION GREATER_EQUAL 13))
+    # GCC for SystemZ: Enable `-fno-semantic-interposition` when using
+    # GCC version >= 10.3 Old versions of GCC seems to have bugs.
+    if ((CMAKE_COMPILER_IS_GNUCXX AND
+	  NOT (LLVM_NATIVE_ARCH STREQUAL "SystemZ"
+	    AND CMAKE_CXX_COMPILER_VERSION VERSION_LESS 10.3))
+	OR (CMAKE_CXX_COMPILER_ID MATCHES "Clang" AND CMAKE_CXX_COMPILER_VERSION GREATER_EQUAL 13))
       add_flag_if_supported("-fno-semantic-interposition" FNO_SEMANTIC_INTERPOSITION)
     endif()
   endif()