diff --git a/clang/lib/Tooling/ExpandResponseFilesCompilationDatabase.cpp b/clang/lib/Tooling/ExpandResponseFilesCompilationDatabase.cpp
--- a/clang/lib/Tooling/ExpandResponseFilesCompilationDatabase.cpp
+++ b/clang/lib/Tooling/ExpandResponseFilesCompilationDatabase.cpp
@@ -54,7 +54,8 @@
       Argv.reserve(Cmd.CommandLine.size());
       for (auto &Arg : Cmd.CommandLine) {
         Argv.push_back(Arg.c_str());
-        SeenRSPFile |= Arg.front() == '@';
+        if (!Arg.empty())
+          SeenRSPFile |= Arg.front() == '@';
       }
       if (!SeenRSPFile)
         continue;
diff --git a/clang/unittests/Tooling/CompilationDatabaseTest.cpp b/clang/unittests/Tooling/CompilationDatabaseTest.cpp
--- a/clang/unittests/Tooling/CompilationDatabaseTest.cpp
+++ b/clang/unittests/Tooling/CompilationDatabaseTest.cpp
@@ -700,6 +700,10 @@
     SmallVector<StringRef, 8> Argv = {Clang, File, "-D", File};
     llvm::SplitString(Flags, Argv);
 
+    // Trim double quotation from the argumnets if any.
+    for (auto It = Argv.begin(); It != Argv.end(); ++It)
+      *It = It->trim("\"");
+
     SmallString<32> Dir;
     llvm::sys::path::system_temp_directory(false, Dir);
 
@@ -962,5 +966,12 @@
   EXPECT_EQ(getCommand("bar.cpp"), "clang bar.cpp -D bar.cpp -Dflag");
 }
 
+TEST_F(ExpandResponseFilesTest, ExpandResponseFilesEmptyArgument) {
+  addFile(path(StringRef("rsp1.rsp")), "-Dflag");
+
+  add("foo.cpp", "clang", "@rsp1.rsp \"\"");
+  EXPECT_EQ(getCommand("foo.cpp"), "clang foo.cpp -D foo.cpp -Dflag ");
+}
+
 } // end namespace tooling
 } // end namespace clang