diff --git a/llvm/lib/Transforms/Instrumentation/ControlHeightReduction.cpp b/llvm/lib/Transforms/Instrumentation/ControlHeightReduction.cpp
--- a/llvm/lib/Transforms/Instrumentation/ControlHeightReduction.cpp
+++ b/llvm/lib/Transforms/Instrumentation/ControlHeightReduction.cpp
@@ -437,6 +437,16 @@
 }
 
 static bool shouldApply(Function &F, ProfileSummaryInfo& PSI) {
+  // If any of the basic blocks have address taken, we should skip this pass
+  // because the cloned blocks by this pass will not have address taken, and
+  // hence they may be optimized out by SimplifyCFG if they are targets of
+  // indirect branches.
+  bool HasBBAddressTaken =
+      llvm::any_of(F.getBasicBlockList(),
+                   [](const BasicBlock &BB) { return BB.hasAddressTaken(); });
+  if (HasBBAddressTaken)
+    return false;
+
   if (ForceCHR)
     return true;