diff --git a/llvm/test/tools/llvm-reduce/remove-args-dbg-intrinsics.ll b/llvm/test/tools/llvm-reduce/remove-args-dbg-intrinsics.ll
new file mode 100644
--- /dev/null
+++ b/llvm/test/tools/llvm-reduce/remove-args-dbg-intrinsics.ll
@@ -0,0 +1,9 @@
+; llvm-reduce shouldn't remove arguments of debug intrinsics, because the resulting module will be ill-formed.
+;
+; RUN: llvm-reduce --abort-on-invalid-reduction --delta-passes=arguments --test=FileCheck --test-arg=%s --output=%t %s
+; CHECK: declare void @llvm.dbg.addr(metadata, metadata, metadata)
+declare void @llvm.dbg.addr(metadata, metadata, metadata)
+; CHECK: declare void @llvm.dbg.declare(metadata, metadata, metadata)
+declare void @llvm.dbg.declare(metadata, metadata, metadata)
+; CHECK: declare void @llvm.dbg.value(metadata, metadata, metadata)
+declare void @llvm.dbg.value(metadata, metadata, metadata)
diff --git a/llvm/tools/llvm-reduce/deltas/ReduceArguments.cpp b/llvm/tools/llvm-reduce/deltas/ReduceArguments.cpp
--- a/llvm/tools/llvm-reduce/deltas/ReduceArguments.cpp
+++ b/llvm/tools/llvm-reduce/deltas/ReduceArguments.cpp
@@ -14,6 +14,7 @@
 #include "ReduceArguments.h"
 #include "Delta.h"
 #include "llvm/ADT/SmallVector.h"
+#include "llvm/IR/Intrinsics.h"
 #include <set>
 #include <vector>
 
@@ -38,6 +39,14 @@
     }
 }
 
+/// Returns whether or not this function should be considered a candidate for
+/// argument removal. Currently, functions with no arguments and intrinsics are
+/// not considered. Intrinsics aren't considered because their signatures are
+/// fixed.
+static bool shouldRemoveArguments(const Function &F) {
+  return !F.arg_empty() && F.getIntrinsicID() == Intrinsic::not_intrinsic;
+}
+
 /// Removes out-of-chunk arguments from functions, and modifies their calls
 /// accordingly. It also removes allocations of out-of-chunk arguments.
 static void extractArgumentsFromModule(std::vector<Chunk> ChunksToKeep,
@@ -48,7 +57,7 @@
   std::vector<Function *> Funcs;
   // Get inside-chunk arguments, as well as their parent function
   for (auto &F : *Program)
-    if (!F.arg_empty()) {
+    if (shouldRemoveArguments(F)) {
       Funcs.push_back(&F);
       for (auto &A : F.args())
         if (O.shouldKeep())
@@ -108,7 +117,7 @@
   outs() << "Param Index Reference:\n";
   int ArgsCount = 0;
   for (auto &F : *Program)
-    if (!F.arg_empty()) {
+    if (shouldRemoveArguments(F)) {
       outs() << "  " << F.getName() << "\n";
       for (auto &A : F.args())
         outs() << "\t" << ++ArgsCount << ": " << A.getName() << "\n";