diff --git a/llvm/lib/Transforms/Scalar/LoopStrengthReduce.cpp b/llvm/lib/Transforms/Scalar/LoopStrengthReduce.cpp
--- a/llvm/lib/Transforms/Scalar/LoopStrengthReduce.cpp
+++ b/llvm/lib/Transforms/Scalar/LoopStrengthReduce.cpp
@@ -2477,7 +2477,7 @@
     // It's possible for the setcc instruction to be anywhere in the loop, and
     // possible for it to have multiple users.  If it is not immediately before
     // the exiting block branch, move it.
-    if (&*++BasicBlock::iterator(Cond) != TermBr) {
+    if (Cond->getNextNonDebugInstruction() != TermBr) {
       if (Cond->hasOneUse()) {
         Cond->moveBefore(TermBr);
       } else {
diff --git a/llvm/test/Transforms/LoopStrengthReduce/X86/lsr-cond-dbg.ll b/llvm/test/Transforms/LoopStrengthReduce/X86/lsr-cond-dbg.ll
new file mode 100644
--- /dev/null
+++ b/llvm/test/Transforms/LoopStrengthReduce/X86/lsr-cond-dbg.ll
@@ -0,0 +1,92 @@
+; RUN: opt -S -loop-reduce < %s | FileCheck %s
+
+; During Loop Strength Reduce, if the terminating condition for the loop is not
+; immediately adjacent to the terminating branch and it has more than one use,
+; a clone of the condition will be created just before the terminating branch
+; and will be used as the branch condition.
+; The purpose of this test is to check that the presence of a debug intrinsic
+; between the condition and branch does not trigger this behaviour, as this
+; would cause debug info to affect CodeGen.
+
+; CHECK-LABEL: i:
+; CHECK-NOT: icmp
+; CHECK: [[COND:%.*]] = icmp eq i8
+; CHECK-NEXT: call void @llvm.dbg.value(metadata i1 [[COND]]
+; CHECK-NEXT: br i1 [[COND]]
+
+
+target datalayout = "e-m:e-p270:32:32-p271:32:32-p272:64:64-i64:64-f80:128-n8:16:32:64-S128"
+target triple = "x86_64-unknown-linux-gnu"
+
+@b = dso_local local_unnamed_addr global i8 0, align 1, !dbg !0
+@a = dso_local local_unnamed_addr global i32 0, align 4, !dbg !6
+@c = dso_local local_unnamed_addr global i8 0, align 1, !dbg !9
+define dso_local signext i16 @d() local_unnamed_addr !dbg !17 {
+entry:
+  %0 = load i32, i32* @a, align 4
+  %tobool2.not = icmp eq i32 %0, 0
+  %1 = load i8, i8* @b, align 1, !dbg !24
+  %cmp.not13 = icmp eq i8 %1, 7, !dbg !24
+  br i1 %cmp.not13, label %cleanup, label %if.end.preheader, !dbg !24
+
+if.end.preheader:                                 ; preds = %entry
+  br label %if.end, !dbg !24
+
+if.end:                                           ; preds = %if.end.preheader, %i
+  %2 = phi i8 [ %add, %i ], [ %1, %if.end.preheader ]
+  br i1 %tobool2.not, label %i, label %if.end4, !dbg !24
+
+if.end4:                                          ; preds = %if.end
+  %conv5 = trunc i32 %0 to i16, !dbg !24
+  br label %cleanup, !dbg !24
+
+i:                                                ; preds = %if.end
+  %add = add i8 %2, 1, !dbg !24
+  store i8 %add, i8* @b, align 1, !dbg !24
+  %cmp.not = icmp eq i8 %add, 7, !dbg !24
+  call void @llvm.dbg.value(metadata i1 %cmp.not, metadata !23, metadata !DIExpression(DW_OP_LLVM_convert, 1, DW_ATE_unsigned, DW_OP_LLVM_convert, 32, DW_ATE_unsigned, DW_OP_stack_value)), !dbg !24
+  br i1 %cmp.not, label %cleanup.loopexit, label %if.end, !dbg !24
+
+cleanup.loopexit:                                 ; preds = %i
+  br label %cleanup
+
+cleanup:                                          ; preds = %cleanup.loopexit, %if.end4, %entry
+  %cmp.not12 = phi i1 [ %cmp.not13, %if.end4 ], [ %cmp.not13, %entry ], [ %cmp.not, %cleanup.loopexit ]
+  %retval.0 = phi i16 [ %conv5, %if.end4 ], [ undef, %entry ], [ undef, %cleanup.loopexit ]
+  %3 = load i8, i8* @c, align 1
+  %conv8 = sext i8 %3 to i16
+  %retval.1 = select i1 %cmp.not12, i16 %conv8, i16 %retval.0
+  ret i16 %retval.1, !dbg !24
+}
+
+declare void @llvm.dbg.value(metadata, metadata, metadata)
+
+!llvm.dbg.cu = !{!2}
+!llvm.module.flags = !{!12, !13, !14, !15}
+!llvm.ident = !{!16}
+
+!0 = !DIGlobalVariableExpression(var: !1, expr: !DIExpression())
+!1 = distinct !DIGlobalVariable(name: "b", scope: !2, file: !3, line: 2, type: !11, isLocal: false, isDefinition: true)
+!2 = distinct !DICompileUnit(language: DW_LANG_C99, file: !3, producer: "clang version 13.0.0", isOptimized: true, runtimeVersion: 0, emissionKind: FullDebug, enums: !4, globals: !5, splitDebugInlining: false, nameTableKind: None)
+!3 = !DIFile(filename: "lsr-cond-dbg.c", directory: "/")
+!4 = !{}
+!5 = !{!6, !0, !9}
+!6 = !DIGlobalVariableExpression(var: !7, expr: !DIExpression())
+!7 = distinct !DIGlobalVariable(name: "a", scope: !2, file: !3, line: 1, type: !8, isLocal: false, isDefinition: true)
+!8 = !DIBasicType(name: "int", size: 32, encoding: DW_ATE_signed)
+!9 = !DIGlobalVariableExpression(var: !10, expr: !DIExpression())
+!10 = distinct !DIGlobalVariable(name: "c", scope: !2, file: !3, line: 2, type: !11, isLocal: false, isDefinition: true)
+!11 = !DIBasicType(name: "char", size: 8, encoding: DW_ATE_signed_char)
+!12 = !{i32 7, !"Dwarf Version", i32 4}
+!13 = !{i32 2, !"Debug Info Version", i32 3}
+!14 = !{i32 1, !"wchar_size", i32 4}
+!15 = !{i32 7, !"uwtable", i32 1}
+!16 = !{!"clang version 13.0.0"}
+!17 = distinct !DISubprogram(name: "d", scope: !3, file: !3, line: 3, type: !18, scopeLine: 3, flags: DIFlagAllCallsDescribed, spFlags: DISPFlagDefinition | DISPFlagOptimized, unit: !2, retainedNodes: !21)
+!18 = !DISubroutineType(types: !19)
+!19 = !{!20}
+!20 = !DIBasicType(name: "short", size: 16, encoding: DW_ATE_signed)
+!21 = !{!23}
+!22 = distinct !DILexicalBlock(scope: !17, file: !3, line: 4, column: 3)
+!23 = !DILocalVariable(name: "g", scope: !22, file: !3, line: 7, type: !8)
+!24 = !DILocation(line: 5, column: 9, scope: !22)
\ No newline at end of file