diff --git a/llvm/lib/Transforms/Scalar/DeadStoreElimination.cpp b/llvm/lib/Transforms/Scalar/DeadStoreElimination.cpp
--- a/llvm/lib/Transforms/Scalar/DeadStoreElimination.cpp
+++ b/llvm/lib/Transforms/Scalar/DeadStoreElimination.cpp
@@ -56,6 +56,7 @@
 #include "llvm/IR/DataLayout.h"
 #include "llvm/IR/Dominators.h"
 #include "llvm/IR/Function.h"
+#include "llvm/IR/IRBuilder.h"
 #include "llvm/IR/InstIterator.h"
 #include "llvm/IR/InstrTypes.h"
 #include "llvm/IR/Instruction.h"
@@ -78,6 +79,7 @@
 #include "llvm/Support/raw_ostream.h"
 #include "llvm/Transforms/Scalar.h"
 #include "llvm/Transforms/Utils/AssumeBundleBuilder.h"
+#include "llvm/Transforms/Utils/BuildLibCalls.h"
 #include "llvm/Transforms/Utils/Local.h"
 #include <algorithm>
 #include <cassert>
@@ -505,7 +507,11 @@
   BasicBlock::iterator SecondBBI(SecondI);
   BasicBlock *FirstBB = FirstI->getParent();
   BasicBlock *SecondBB = SecondI->getParent();
-  MemoryLocation MemLoc = MemoryLocation::get(SecondI);
+  MemoryLocation MemLoc;
+  if (auto *MemSet = dyn_cast<MemSetInst>(SecondI))
+    MemLoc = MemoryLocation::getForDest(MemSet);
+  else
+    MemLoc = MemoryLocation::get(SecondI);
   auto *MemLocPtr = const_cast<Value *>(MemLoc.Ptr);
 
   // Start checking the SecondBB.
@@ -809,13 +815,17 @@
 }
 
 // Check if we can ignore \p D for DSE.
-bool canSkipDef(MemoryDef *D, bool DefVisibleToCaller) {
+bool canSkipDef(MemoryDef *D, bool DefVisibleToCaller,
+                const TargetLibraryInfo &TLI) {
   Instruction *DI = D->getMemoryInst();
   // Calls that only access inaccessible memory cannot read or write any memory
   // locations we consider for elimination.
   if (auto *CB = dyn_cast<CallBase>(DI))
-    if (CB->onlyAccessesInaccessibleMemory())
+    if (CB->onlyAccessesInaccessibleMemory()) {
+      if (isAllocLikeFn(DI, &TLI))
+        return false;
       return true;
+    }
 
   // We can eliminate stores to locations not visible to the caller across
   // throwing instructions.
@@ -831,7 +841,7 @@
     return true;
 
   // Skip intrinsics that do not really read or modify memory.
-  if (isNoopIntrinsic(D->getMemoryInst()))
+  if (isNoopIntrinsic(DI))
     return true;
 
   return false;
@@ -1375,7 +1385,7 @@
       MemoryDef *CurrentDef = cast<MemoryDef>(Current);
       Instruction *CurrentI = CurrentDef->getMemoryInst();
 
-      if (canSkipDef(CurrentDef, !isInvisibleToCallerBeforeRet(DefUO))) {
+      if (canSkipDef(CurrentDef, !isInvisibleToCallerBeforeRet(DefUO), TLI)) {
         StepAgain = true;
         Current = CurrentDef->getDefiningAccess();
         continue;
@@ -1808,13 +1818,45 @@
 
     if (StoredConstant && StoredConstant->isNullValue()) {
       auto *DefUOInst = dyn_cast<Instruction>(DefUO);
-      if (DefUOInst && isCallocLikeFn(DefUOInst, &TLI)) {
-        auto *UnderlyingDef = cast<MemoryDef>(MSSA.getMemoryAccess(DefUOInst));
-        // If UnderlyingDef is the clobbering access of Def, no instructions
-        // between them can modify the memory location.
-        auto *ClobberDef =
-            MSSA.getSkipSelfWalker()->getClobberingMemoryAccess(Def);
-        return UnderlyingDef == ClobberDef;
+      if (DefUOInst) {
+        if (isCallocLikeFn(DefUOInst, &TLI)) {
+          auto *UnderlyingDef =
+              cast<MemoryDef>(MSSA.getMemoryAccess(DefUOInst));
+          // If UnderlyingDef is the clobbering access of Def, no instructions
+          // between them can modify the memory location.
+          auto *ClobberDef =
+              MSSA.getSkipSelfWalker()->getClobberingMemoryAccess(Def);
+          return UnderlyingDef == ClobberDef;
+        }
+
+        if (MemSet) {
+          auto *Malloc = const_cast<CallInst *>(dyn_cast<CallInst>(DefUOInst));
+          if (!Malloc)
+            return false;
+          auto *InnerCallee = Malloc->getCalledFunction();
+          if (!InnerCallee)
+            return false;
+          LibFunc Func;
+          if (!TLI.getLibFunc(*InnerCallee, Func) || !TLI.has(Func) ||
+              Func != LibFunc_malloc)
+            return false;
+          if (Malloc->getOperand(0) == MemSet->getLength()) {
+            if (DT.dominates(DefUOInst, MemSet) &&
+                memoryIsNotModifiedBetween(Malloc, MemSet, BatchAA, DL, &DT)) {
+              IRBuilder<> IRB(Malloc);
+              const auto &DL = Malloc->getModule()->getDataLayout();
+              AttributeList EmptyList;
+              if (auto *Calloc = emitCalloc(
+                      ConstantInt::get(IRB.getIntPtrTy(DL), 1),
+                      Malloc->getArgOperand(0), EmptyList, IRB, TLI)) {
+                Malloc->replaceAllUsesWith(Calloc);
+                Malloc->eraseFromParent();
+                return true;
+              }
+              return false;
+            }
+          }
+        }
       }
     }
 
diff --git a/llvm/test/Transforms/DeadStoreElimination/noop-stores.ll b/llvm/test/Transforms/DeadStoreElimination/noop-stores.ll
--- a/llvm/test/Transforms/DeadStoreElimination/noop-stores.ll
+++ b/llvm/test/Transforms/DeadStoreElimination/noop-stores.ll
@@ -309,6 +309,36 @@
   ret void
 }
 
+declare noalias i8* @malloc(i64)
+declare void @clobber_memory(float*)
+
+; based on pr25892_lite
+define i8* @zero_memset_after_malloc(i64 %size) {
+; CHECK-LABEL: @zero_memset_after_malloc(
+; CHECK-NEXT:    [[CALL:%.*]] = call i8* @calloc(i64 1, i64 [[SIZE:%.*]])
+; CHECK-NEXT:    ret i8* [[CALL]]
+;
+  %call = call i8* @malloc(i64 %size) inaccessiblememonly
+  call void @llvm.memset.p0i8.i64(i8* %call, i8 0, i64 %size, i1 false)
+  ret i8* %call
+}
+
+; based on pr25892_lite
+define i8* @zero_memset_after_malloc_with_intermediate_clobbering(i64 %size) {
+; CHECK-LABEL: @zero_memset_after_malloc_with_intermediate_clobbering(
+; CHECK-NEXT:    [[CALL:%.*]] = call i8* @malloc(i64 [[SIZE:%.*]])
+; CHECK-NEXT:    [[BC:%.*]] = bitcast i8* [[CALL]] to float*
+; CHECK-NEXT:    call void @clobber_memory(float* [[BC]])
+; CHECK-NEXT:    call void @llvm.memset.p0i8.i64(i8* [[CALL]], i8 0, i64 [[SIZE]], i1 false)
+; CHECK-NEXT:    ret i8* [[CALL]]
+;
+  %call = call i8* @malloc(i64 %size) inaccessiblememonly
+  %bc = bitcast i8* %call to float*
+  call void @clobber_memory(float* %bc)
+  call void @llvm.memset.p0i8.i64(i8* %call, i8 0, i64 %size, i1 false)
+  ret i8* %call
+}
+
 ; PR50143
 define i8* @store_zero_after_calloc_inaccessiblememonly() {
 ; CHECK-LABEL: @store_zero_after_calloc_inaccessiblememonly(