diff --git a/clang/lib/Driver/ToolChains/AMDGPU.h b/clang/lib/Driver/ToolChains/AMDGPU.h
--- a/clang/lib/Driver/ToolChains/AMDGPU.h
+++ b/clang/lib/Driver/ToolChains/AMDGPU.h
@@ -107,7 +107,19 @@
 
 protected:
   /// Check and diagnose invalid target ID specified by -mcpu.
-  void checkTargetID(const llvm::opt::ArgList &DriverArgs) const;
+  virtual void checkTargetID(const llvm::opt::ArgList &DriverArgs) const;
+
+  /// The struct type returned by getParsedTargetID.
+  struct ParsedTargetIDType {
+    Optional<std::string> OptionalTargetID;
+    Optional<std::string> OptionalGPUArch;
+    Optional<llvm::StringMap<bool>> OptionalFeatures;
+  };
+
+  /// Get target ID, GPU arch, and target ID features if the target ID is
+  /// specified and valid.
+  ParsedTargetIDType
+  getParsedTargetID(const llvm::opt::ArgList &DriverArgs) const;
 
   /// Get GPU arch from -mcpu without checking.
   StringRef getGPUArch(const llvm::opt::ArgList &DriverArgs) const;
diff --git a/clang/lib/Driver/ToolChains/AMDGPU.cpp b/clang/lib/Driver/ToolChains/AMDGPU.cpp
--- a/clang/lib/Driver/ToolChains/AMDGPU.cpp
+++ b/clang/lib/Driver/ToolChains/AMDGPU.cpp
@@ -707,16 +707,26 @@
       getTriple(), DriverArgs.getLastArgValue(options::OPT_mcpu_EQ));
 }
 
-void AMDGPUToolChain::checkTargetID(
-    const llvm::opt::ArgList &DriverArgs) const {
+AMDGPUToolChain::ParsedTargetIDType
+AMDGPUToolChain::getParsedTargetID(const llvm::opt::ArgList &DriverArgs) const {
   StringRef TargetID = DriverArgs.getLastArgValue(options::OPT_mcpu_EQ);
   if (TargetID.empty())
-    return;
+    return {None, None, None};
 
   llvm::StringMap<bool> FeatureMap;
   auto OptionalGpuArch = parseTargetID(getTriple(), TargetID, &FeatureMap);
-  if (!OptionalGpuArch) {
-    getDriver().Diag(clang::diag::err_drv_bad_target_id) << TargetID;
+  if (!OptionalGpuArch)
+    return {TargetID.str(), None, None};
+
+  return {TargetID.str(), OptionalGpuArch.getValue().str(), FeatureMap};
+}
+
+void AMDGPUToolChain::checkTargetID(
+    const llvm::opt::ArgList &DriverArgs) const {
+  auto PTID = getParsedTargetID(DriverArgs);
+  if (PTID.OptionalTargetID && !PTID.OptionalGPUArch) {
+    getDriver().Diag(clang::diag::err_drv_bad_target_id)
+        << PTID.OptionalTargetID.getValue();
   }
 }
 
diff --git a/clang/lib/Driver/ToolChains/HIP.h b/clang/lib/Driver/ToolChains/HIP.h
--- a/clang/lib/Driver/ToolChains/HIP.h
+++ b/clang/lib/Driver/ToolChains/HIP.h
@@ -95,6 +95,7 @@
   unsigned GetDefaultDwarfVersion() const override { return 4; }
 
   const ToolChain &HostTC;
+  void checkTargetID(const llvm::opt::ArgList &DriverArgs) const override;
 
 protected:
   Tool *buildLinker() const override;
diff --git a/clang/lib/Driver/ToolChains/HIP.cpp b/clang/lib/Driver/ToolChains/HIP.cpp
--- a/clang/lib/Driver/ToolChains/HIP.cpp
+++ b/clang/lib/Driver/ToolChains/HIP.cpp
@@ -459,3 +459,28 @@
 
   return BCLibs;
 }
+
+void HIPToolChain::checkTargetID(const llvm::opt::ArgList &DriverArgs) const {
+  auto PTID = getParsedTargetID(DriverArgs);
+  if (PTID.OptionalTargetID && !PTID.OptionalGPUArch) {
+    getDriver().Diag(clang::diag::err_drv_bad_target_id)
+        << PTID.OptionalTargetID.getValue();
+    return;
+  }
+
+  assert(PTID.OptionalFeatures && "Invalid return from getParsedTargetID");
+  auto &FeatureMap = PTID.OptionalFeatures.getValue();
+  // Sanitizer is not supported with xnack-.
+  if (DriverArgs.hasFlag(options::OPT_fgpu_sanitize,
+                         options::OPT_fno_gpu_sanitize, false)) {
+    auto Loc = FeatureMap.find("xnack");
+    if (Loc != FeatureMap.end() && !Loc->second) {
+      auto &Diags = getDriver().getDiags();
+      auto DiagID = Diags.getCustomDiagID(
+          DiagnosticsEngine::Error,
+          "'-fgpu-sanitize' is not compatible with offload arch '%0'. "
+          "Use an offload arch without 'xnack-' instead");
+      Diags.Report(DiagID) << PTID.OptionalTargetID.getValue();
+    }
+  }
+}
diff --git a/clang/test/Driver/hip-sanitize-options.hip b/clang/test/Driver/hip-sanitize-options.hip
--- a/clang/test/Driver/hip-sanitize-options.hip
+++ b/clang/test/Driver/hip-sanitize-options.hip
@@ -25,6 +25,11 @@
 // RUN:   -nogpuinc --rocm-path=%S/Inputs/rocm-invalid \
 // RUN:   %s 2>&1 | FileCheck -check-prefixes=FAIL %s
 
+// RUN: %clang -### -target x86_64-unknown-linux-gnu --offload-arch=gfx900:xnack- \
+// RUN:   -fsanitize=address -fgpu-sanitize \
+// RUN:   -nogpuinc --rocm-path=%S/Inputs/rocm \
+// RUN:   %s 2>&1 | FileCheck -check-prefix=XNACK %s
+
 // CHECK-NOT: {{"[^"]*clang[^"]*".* "-fcuda-is-device".* "-fsanitize=address"}}
 // CHECK-NOT: {{"[^"]*lld(\.exe){0,1}".* ".*hip.bc"}}
 // CHECK: {{"[^"]*clang[^"]*".* "-triple" "x86_64-unknown-linux-gnu".* "-fsanitize=address"}}
@@ -38,3 +43,5 @@
 // RDC: {{"[^"]*lld(\.exe){0,1}".*}} "[[OUT]]" {{".*asanrtl.bc" ".*hip.bc"}}
 
 // FAIL: AMDGPU address sanitizer runtime library (asanrtl) is not found. Please install ROCm device library which supports address sanitizer
+
+// XNACK: error: '-fgpu-sanitize' is not compatible with offload arch 'gfx900:xnack-'. Use an offload arch without 'xnack-' instead