diff --git a/llvm/cmake/modules/HandleLLVMOptions.cmake b/llvm/cmake/modules/HandleLLVMOptions.cmake
--- a/llvm/cmake/modules/HandleLLVMOptions.cmake
+++ b/llvm/cmake/modules/HandleLLVMOptions.cmake
@@ -305,6 +305,16 @@
     # On Windows all code is PIC. MinGW warns if -fPIC is used.
   else()
     add_flag_or_print_warning("-fPIC" FPIC)
+    # Enable interprocedural optimizations for non-inline functions which would
+    # otherwise be disabled due to GCC -fPIC's default.
+    #
+    # Note: Clang allows IPO for -fPIC so this optimization is less effective.
+    # On ELF targets, -fno-pic compiled user programs may cause copy relocations
+    # if they access global/static variables declared in LLVM's public headers.
+    # This is incompatible with Clang's extra optimization on global variables.
+    if (CMAKE_CXX_COMPILER_ID STREQUAL "GNU")
+      add_flag_if_supported("-fno-semantic-interposition" FNO_SEMANTIC_INTERPOSITION)
+    endif()
   endif()
   # GCC for MIPS can miscompile LLVM due to PR37701.
   if(CMAKE_COMPILER_IS_GNUCXX AND LLVM_NATIVE_ARCH STREQUAL "Mips" AND