diff --git a/llvm/lib/Target/AMDGPU/SIInsertHardClauses.cpp b/llvm/lib/Target/AMDGPU/SIInsertHardClauses.cpp
--- a/llvm/lib/Target/AMDGPU/SIInsertHardClauses.cpp
+++ b/llvm/lib/Target/AMDGPU/SIInsertHardClauses.cpp
@@ -76,6 +76,13 @@
   }
 
   HardClauseType getHardClauseType(const MachineInstr &MI) {
+    // Do not clause NSA instructions on GFX10.
+    if (AMDGPU::isGFX10(*ST) && ST->hasFeature(AMDGPU::FeatureNSAEncoding)) {
+      const AMDGPU::MIMGInfo *Info = AMDGPU::getMIMGInfo(MI.getOpcode());
+      if (Info && Info->MIMGEncoding == AMDGPU::MIMGEncGfx10NSA)
+        return HARDCLAUSE_ILLEGAL;
+    }
+
     // On current architectures we only get a benefit from clausing loads.
     if (MI.mayLoad()) {
       if (SIInstrInfo::isVMEM(MI) || SIInstrInfo::isSegmentSpecificFLAT(MI))
diff --git a/llvm/test/CodeGen/AMDGPU/cluster_stores.ll b/llvm/test/CodeGen/AMDGPU/cluster_stores.ll
--- a/llvm/test/CodeGen/AMDGPU/cluster_stores.ll
+++ b/llvm/test/CodeGen/AMDGPU/cluster_stores.ll
@@ -359,7 +359,6 @@
 ; GFX10-NEXT:    v_add_f32_e32 v12, 1.0, v3
 ; GFX10-NEXT:    v_add_f32_e32 v14, 2.0, v2
 ; GFX10-NEXT:    v_add_f32_e32 v15, 2.0, v3
-; GFX10-NEXT:    s_clause 0x1
 ; GFX10-NEXT:    image_sample_d v[2:5], [v11, v12, v13, v13, v13, v13], s[0:7], s[8:11] dmask:0xf dim:SQ_RSRC_IMG_2D
 ; GFX10-NEXT:    image_sample_d v[6:9], [v14, v15, v10, v10, v10, v10], s[0:7], s[8:11] dmask:0xf dim:SQ_RSRC_IMG_2D
 ; GFX10-NEXT:    s_waitcnt vmcnt(0)
diff --git a/llvm/test/CodeGen/AMDGPU/hard-clauses.mir b/llvm/test/CodeGen/AMDGPU/hard-clauses.mir
--- a/llvm/test/CodeGen/AMDGPU/hard-clauses.mir
+++ b/llvm/test/CodeGen/AMDGPU/hard-clauses.mir
@@ -209,3 +209,33 @@
     $vgpr79 = BUFFER_LOAD_DWORD_OFFEN $vgpr0, $sgpr0_sgpr1_sgpr2_sgpr3, 0, 316, 0, 0, 0, implicit $exec
     $vgpr80 = BUFFER_LOAD_DWORD_OFFEN $vgpr0, $sgpr0_sgpr1_sgpr2_sgpr3, 0, 320, 0, 0, 0, implicit $exec
 ...
+
+---
+name: mimg_nsa
+tracksRegLiveness: true
+body: |
+  bb.0:
+    liveins: $sgpr0_sgpr1_sgpr2_sgpr3_sgpr4_sgpr5_sgpr6_sgpr7, $sgpr8_sgpr9_sgpr10_sgpr11, $vgpr0, $vgpr1, $vgpr2, $vgpr3, $vgpr4, $vgpr5, $vgpr6, $vgpr7, $vgpr8
+    ; CHECK-LABEL: name: mimg_nsa
+    ; CHECK: liveins: $sgpr0_sgpr1_sgpr2_sgpr3_sgpr4_sgpr5_sgpr6_sgpr7, $sgpr8_sgpr9_sgpr10_sgpr11, $vgpr0, $vgpr1, $vgpr2, $vgpr3, $vgpr4, $vgpr5, $vgpr6, $vgpr7, $vgpr8
+    ; CHECK: $vgpr10_vgpr11_vgpr12_vgpr13 = IMAGE_SAMPLE_D_V4_V9_nsa_gfx10 $vgpr3, $vgpr8, $vgpr7, $vgpr5, $vgpr4, $vgpr6, $vgpr0, $vgpr2, $vgpr2, $sgpr0_sgpr1_sgpr2_sgpr3_sgpr4_sgpr5_sgpr6_sgpr7, $sgpr8_sgpr9_sgpr10_sgpr11, 15, 2, 0, 0, 0, 0, 0, 0, 0, implicit $exec :: (load 16)
+    ; CHECK: $vgpr20_vgpr21_vgpr22_vgpr23 = IMAGE_SAMPLE_D_V4_V9_nsa_gfx10 $vgpr3, $vgpr8, $vgpr7, $vgpr5, $vgpr4, $vgpr6, $vgpr0, $vgpr2, $vgpr2, $sgpr0_sgpr1_sgpr2_sgpr3_sgpr4_sgpr5_sgpr6_sgpr7, $sgpr8_sgpr9_sgpr10_sgpr11, 15, 2, 0, 0, 0, 0, 0, 0, 0, implicit $exec :: (load 16)
+    $vgpr10_vgpr11_vgpr12_vgpr13 = IMAGE_SAMPLE_D_V4_V9_nsa_gfx10 $vgpr3, $vgpr8, $vgpr7, $vgpr5, $vgpr4, $vgpr6, $vgpr0, $vgpr2, $vgpr2, $sgpr0_sgpr1_sgpr2_sgpr3_sgpr4_sgpr5_sgpr6_sgpr7, $sgpr8_sgpr9_sgpr10_sgpr11, 15, 2, 0, 0, 0, 0, 0, 0, 0, implicit $exec  :: (load 16)
+    $vgpr20_vgpr21_vgpr22_vgpr23 = IMAGE_SAMPLE_D_V4_V9_nsa_gfx10 $vgpr3, $vgpr8, $vgpr7, $vgpr5, $vgpr4, $vgpr6, $vgpr0, $vgpr2, $vgpr2, $sgpr0_sgpr1_sgpr2_sgpr3_sgpr4_sgpr5_sgpr6_sgpr7, $sgpr8_sgpr9_sgpr10_sgpr11, 15, 2, 0, 0, 0, 0, 0, 0, 0, implicit $exec  :: (load 16)
+...
+
+---
+name: mimg_nsa_mixed
+tracksRegLiveness: true
+body: |
+  bb.0:
+    liveins: $sgpr0_sgpr1_sgpr2_sgpr3_sgpr4_sgpr5_sgpr6_sgpr7, $sgpr8_sgpr9_sgpr10_sgpr11, $vgpr0, $vgpr1, $vgpr2, $vgpr3, $vgpr4, $vgpr5, $vgpr6, $vgpr7, $vgpr8
+    ; CHECK-LABEL: name: mimg_nsa_mixed
+    ; CHECK: liveins: $sgpr0_sgpr1_sgpr2_sgpr3_sgpr4_sgpr5_sgpr6_sgpr7, $sgpr8_sgpr9_sgpr10_sgpr11, $vgpr0, $vgpr1, $vgpr2, $vgpr3, $vgpr4, $vgpr5, $vgpr6, $vgpr7, $vgpr8
+    ; CHECK: $vgpr10_vgpr11_vgpr12_vgpr13 = IMAGE_SAMPLE_D_V4_V9_nsa_gfx10 $vgpr3, $vgpr8, $vgpr7, $vgpr5, $vgpr4, $vgpr6, $vgpr0, $vgpr2, $vgpr2, $sgpr0_sgpr1_sgpr2_sgpr3_sgpr4_sgpr5_sgpr6_sgpr7, $sgpr8_sgpr9_sgpr10_sgpr11, 15, 2, 0, 0, 0, 0, 0, 0, 0, implicit $exec :: (load 16)
+    ; CHECK: $vgpr14 = IMAGE_SAMPLE_LZ_V1_V2_gfx10 $vgpr5_vgpr6, $sgpr0_sgpr1_sgpr2_sgpr3_sgpr4_sgpr5_sgpr6_sgpr7, $sgpr8_sgpr9_sgpr10_sgpr11, 1, 1, 0, 0, 0, 0, 0, 0, 0, implicit $exec :: (dereferenceable load 16 from custom "ImageResource")
+    ; CHECK: $vgpr20_vgpr21_vgpr22_vgpr23 = IMAGE_SAMPLE_D_V4_V9_nsa_gfx10 $vgpr3, $vgpr8, $vgpr7, $vgpr5, $vgpr4, $vgpr6, $vgpr0, $vgpr2, $vgpr2, $sgpr0_sgpr1_sgpr2_sgpr3_sgpr4_sgpr5_sgpr6_sgpr7, $sgpr8_sgpr9_sgpr10_sgpr11, 15, 2, 0, 0, 0, 0, 0, 0, 0, implicit $exec :: (load 16)
+    $vgpr10_vgpr11_vgpr12_vgpr13 = IMAGE_SAMPLE_D_V4_V9_nsa_gfx10 $vgpr3, $vgpr8, $vgpr7, $vgpr5, $vgpr4, $vgpr6, $vgpr0, $vgpr2, $vgpr2, $sgpr0_sgpr1_sgpr2_sgpr3_sgpr4_sgpr5_sgpr6_sgpr7, $sgpr8_sgpr9_sgpr10_sgpr11, 15, 2, 0, 0, 0, 0, 0, 0, 0, implicit $exec  :: (load 16)
+    $vgpr14 = IMAGE_SAMPLE_LZ_V1_V2_gfx10 $vgpr5_vgpr6, $sgpr0_sgpr1_sgpr2_sgpr3_sgpr4_sgpr5_sgpr6_sgpr7, $sgpr8_sgpr9_sgpr10_sgpr11, 1, 1, 0, 0, 0, 0, 0, 0, 0, implicit $exec :: (dereferenceable load 16 from custom "ImageResource")
+    $vgpr20_vgpr21_vgpr22_vgpr23 = IMAGE_SAMPLE_D_V4_V9_nsa_gfx10 $vgpr3, $vgpr8, $vgpr7, $vgpr5, $vgpr4, $vgpr6, $vgpr0, $vgpr2, $vgpr2, $sgpr0_sgpr1_sgpr2_sgpr3_sgpr4_sgpr5_sgpr6_sgpr7, $sgpr8_sgpr9_sgpr10_sgpr11, 15, 2, 0, 0, 0, 0, 0, 0, 0, implicit $exec  :: (load 16)
+...