diff --git a/clang/include/clang/Driver/Options.td b/clang/include/clang/Driver/Options.td
--- a/clang/include/clang/Driver/Options.td
+++ b/clang/include/clang/Driver/Options.td
@@ -3254,6 +3254,8 @@
 def mno_altivec : Flag<["-"], "mno-altivec">, Group<m_ppc_Features_Group>;
 def mpcrel: Flag<["-"], "mpcrel">, Group<m_ppc_Features_Group>;
 def mno_pcrel: Flag<["-"], "mno-pcrel">, Group<m_ppc_Features_Group>;
+def mprefixed: Flag<["-"], "mprefixed">, Group<m_ppc_Features_Group>;
+def mno_prefixed: Flag<["-"], "mno-prefixed">, Group<m_ppc_Features_Group>;
 def mspe : Flag<["-"], "mspe">, Group<m_ppc_Features_Group>;
 def mno_spe : Flag<["-"], "mno-spe">, Group<m_ppc_Features_Group>;
 def mefpu2 : Flag<["-"], "mefpu2">, Group<m_ppc_Features_Group>;
diff --git a/clang/lib/Basic/Targets/PPC.h b/clang/lib/Basic/Targets/PPC.h
--- a/clang/lib/Basic/Targets/PPC.h
+++ b/clang/lib/Basic/Targets/PPC.h
@@ -73,6 +73,7 @@
   bool PairedVectorMemops = false;
   bool HasP10Vector = false;
   bool HasPCRelativeMemops = false;
+  bool HasPrefixInstrs = false;
 
 protected:
   std::string ABI;
diff --git a/clang/lib/Basic/Targets/PPC.cpp b/clang/lib/Basic/Targets/PPC.cpp
--- a/clang/lib/Basic/Targets/PPC.cpp
+++ b/clang/lib/Basic/Targets/PPC.cpp
@@ -56,6 +56,8 @@
       HasP10Vector = true;
     } else if (Feature == "+pcrelative-memops") {
       HasPCRelativeMemops = true;
+    } else if (Feature == "+prefix-instrs") {
+      HasPrefixInstrs = true;
     } else if (Feature == "+spe" || Feature == "+efpu2") {
       HasSPE = true;
       LongDoubleWidth = LongDoubleAlign = 64;
@@ -394,6 +396,7 @@
   Features["mma"] = true;
   Features["power10-vector"] = true;
   Features["pcrelative-memops"] = true;
+  Features["prefix-instrs"] = true;
   return;
 }
 
@@ -419,6 +422,7 @@
       .Case("paired-vector-memops", PairedVectorMemops)
       .Case("power10-vector", HasP10Vector)
       .Case("pcrelative-memops", HasPCRelativeMemops)
+      .Case("prefix-instrs", HasPrefixInstrs)
       .Case("spe", HasSPE)
       .Case("mma", HasMMA)
       .Case("rop-protect", HasROPProtect)
@@ -451,6 +455,8 @@
       Features["power8-vector"] = Features["power9-vector"] = true;
     if (Name == "pcrel")
       Features["pcrelative-memops"] = true;
+    else if (Name == "prefixed")
+      Features["prefix-instrs"] = true;
     else
       Features[Name] = true;
   } else {
@@ -471,6 +477,8 @@
           Features["power10-vector"] = false;
     if (Name == "pcrel")
       Features["pcrelative-memops"] = false;
+    else if (Name == "prefixed")
+      Features["prefix-instrs"] = false;
     else
       Features[Name] = false;
   }
diff --git a/clang/test/Driver/ppc-prefixed.cpp b/clang/test/Driver/ppc-prefixed.cpp
new file mode 100644
--- /dev/null
+++ b/clang/test/Driver/ppc-prefixed.cpp
@@ -0,0 +1,12 @@
+// RUN: %clang -target powerpc64-unknown-linux-gnu %s -### -mcpu=pwr10 -mprefixed -o %t.o 2>&1 | FileCheck -check-prefix=CHECK-PREFIXED %s
+// RUN: %clang -target powerpc64-unknown-linux-gnu %s -### -mcpu=pwr10 -mno-prefixed -o %t.o 2>&1 | FileCheck -check-prefix=CHECK-NOPREFIXED %s
+// CHECK-NOPREFIXED: "-target-feature" "-prefixed"
+// CHECK-PREFIXED: "-target-feature" "+prefixed"
+
+// RUN: %clang -target powerpc64-unknown-linux-gnu -mcpu=pwr10 -emit-llvm -S %s -o - | grep "attributes.*+prefix-instrs"
+// RUN: %clang -target powerpc64-unknown-linux-gnu -mcpu=pwr10 -mprefixed -emit-llvm -S %s -o - | grep "attributes.*+prefix-instrs"
+// RUN: %clang -target powerpc64-unknown-linux-gnu -mcpu=pwr10 -mno-prefixed -emit-llvm -S %s -o - | grep "attributes.*\-prefix-instrs"
+
+int main(int argc, char *argv[]) {
+  return 0;
+}