diff --git a/mlir/lib/Bindings/Python/IRCore.cpp b/mlir/lib/Bindings/Python/IRCore.cpp
--- a/mlir/lib/Bindings/Python/IRCore.cpp
+++ b/mlir/lib/Bindings/Python/IRCore.cpp
@@ -2094,6 +2094,8 @@
                   py::arg("successors") = py::none(), py::arg("regions") = 0,
                   py::arg("loc") = py::none(), py::arg("ip") = py::none(),
                   kOperationCreateDocstring)
+      .def("destroy",
+           [](PyOperation &self) { mlirOperationDestroy(self.get()); })
       .def_property_readonly(MLIR_PYTHON_CAPI_PTR_ATTR,
                              &PyOperation::getCapsule)
       .def(MLIR_PYTHON_CAPI_FACTORY_ATTR, &PyOperation::createFromCapsule)
diff --git a/mlir/test/Bindings/Python/ir_operation.py b/mlir/test/Bindings/Python/ir_operation.py
--- a/mlir/test/Bindings/Python/ir_operation.py
+++ b/mlir/test/Bindings/Python/ir_operation.py
@@ -646,3 +646,22 @@
     assert m2 is m
 
 run(testCapsuleConversions)
+
+# CHECK-LABEL: TEST: testOperationDestroy
+def testOperationDestroy():
+  ctx = Context()
+  ctx.allow_unregistered_dialects = True
+  with Location.unknown(ctx):
+    m = Module.create()
+    with InsertionPoint(m.body):
+      op = Operation.create("custom.op1")
+
+      # CHECK: "custom.op1"
+      print(m)
+
+      op.operation.destroy()
+
+      # CHECK-NOT: "custom.op1"
+      print(m)
+
+run(testOperationDestroy)