diff --git a/clang/lib/Headers/intrin.h b/clang/lib/Headers/intrin.h
--- a/clang/lib/Headers/intrin.h
+++ b/clang/lib/Headers/intrin.h
@@ -507,16 +507,26 @@
 |* Misc
 \*----------------------------------------------------------------------------*/
 #if defined(__i386__) || defined(__x86_64__)
+#if defined(__i386__)
+#define __cpuid_count(__leaf, __count, __eax, __ebx, __ecx, __edx)             \
+  __asm("cpuid"                                                                \
+        : "=a"(__eax), "=b"(__ebx), "=c"(__ecx), "=d"(__edx)                   \
+        : "0"(__leaf), "2"(__count))
+#else
+/* x86-64 uses %rbx as the base register, so preserve it. */
+#define __cpuid_count(__leaf, __count, __eax, __ebx, __ecx, __edx)             \
+  __asm("xchgq %%rbx,%q1\n"                                                    \
+        "cpuid\n"                                                              \
+        "xchgq %%rbx,%q1"                                                      \
+        : "=a"(__eax), "=r"(__ebx), "=c"(__ecx), "=d"(__edx)                   \
+        : "0"(__leaf), "2"(__count))
+#endif
 static __inline__ void __DEFAULT_FN_ATTRS __cpuid(int __info[4], int __level) {
-  __asm__("cpuid"
-          : "=a"(__info[0]), "=b"(__info[1]), "=c"(__info[2]), "=d"(__info[3])
-          : "a"(__level), "c"(0));
+  __cpuid_count(__level, 0, __info[0], __info[1], __info[2], __info[3]);
 }
 static __inline__ void __DEFAULT_FN_ATTRS __cpuidex(int __info[4], int __level,
                                                     int __ecx) {
-  __asm__("cpuid"
-          : "=a"(__info[0]), "=b"(__info[1]), "=c"(__info[2]), "=d"(__info[3])
-          : "a"(__level), "c"(__ecx));
+  __cpuid_count(__level, __ecx, __info[0], __info[1], __info[2], __info[3]);
 }
 static __inline__ void __DEFAULT_FN_ATTRS __halt(void) {
   __asm__ volatile("hlt");
diff --git a/clang/test/CodeGen/ms-intrinsics-cpuid.c b/clang/test/CodeGen/ms-intrinsics-cpuid.c
--- a/clang/test/CodeGen/ms-intrinsics-cpuid.c
+++ b/clang/test/CodeGen/ms-intrinsics-cpuid.c
@@ -1,7 +1,7 @@
 // RUN: %clang_cc1 -ffreestanding -fms-extensions -fms-compatibility -fms-compatibility-version=17.00 \
-// RUN:         -triple i686-windows-msvc -emit-llvm %s -o - | FileCheck %s
+// RUN:         -triple i686-windows-msvc -emit-llvm %s -o - | FileCheck %s --check-prefix=X86
 // RUN: %clang_cc1 -ffreestanding -fms-extensions -fms-compatibility -fms-compatibility-version=17.00 \
-// RUN:         -triple x86_64-windows-msvc -emit-llvm %s -o - | FileCheck %s
+// RUN:         -triple x86_64-windows-msvc -emit-llvm %s -o - | FileCheck %s --check-prefix=X64
 
 // intrin.h needs size_t, but -ffreestanding prevents us from getting it from
 // stddef.h.  Work around it with this typedef.
@@ -12,7 +12,12 @@
 void test__cpuid(int *info, int level) {
   __cpuid(info, level);
 }
-// CHECK-LABEL: define {{.*}} @test__cpuid(i32* %{{.*}}, i32 %{{.*}})
-// CHECK: call { i32, i32, i32, i32 } asm "cpuid",
-// CHECK-SAME:   "={ax},={bx},={cx},={dx},{ax},{cx},~{dirflag},~{fpsr},~{flags}"
-// CHECK-SAME:   (i32 %{{.*}}, i32 0)
+// X86-LABEL: define {{.*}} @test__cpuid(i32* %{{.*}}, i32 %{{.*}})
+// X86: call { i32, i32, i32, i32 } asm "cpuid",
+// X86-SAME:   "={ax},={bx},={cx},={dx},0,2,~{dirflag},~{fpsr},~{flags}"
+// X86-SAME:   (i32 %{{.*}}, i32 0)
+
+// X64-LABEL: define {{.*}} @test__cpuid(i32* %{{.*}}, i32 %{{.*}})
+// X64: call { i32, i32, i32, i32 } asm "xchgq %rbx{{.*}}cpuid{{.*}}xchgq %rbx{{.*}}",
+// X64-SAME:   "={ax},=r,={cx},={dx},0,2,~{dirflag},~{fpsr},~{flags}"
+// X64-SAME:   (i32 %{{.*}}, i32 0)