diff --git a/openmp/libomptarget/deviceRTLs/nvptx/test/lit.cfg b/openmp/libomptarget/deviceRTLs/nvptx/test/lit.cfg
--- a/openmp/libomptarget/deviceRTLs/nvptx/test/lit.cfg
+++ b/openmp/libomptarget/deviceRTLs/nvptx/test/lit.cfg
@@ -44,6 +44,8 @@
 prepend_library_path('LIBRARY_PATH', config.library_dir, ":")
 prepend_library_path('LD_LIBRARY_PATH', config.library_dir, ":")
 prepend_library_path('LD_LIBRARY_PATH', config.omp_host_rtl_directory, ":")
+if config.cuda_libdir:
+    prepend_library_path('LD_LIBRARY_PATH', config.cuda_libdir, ":")
 
 # Forbid fallback to host.
 config.environment["OMP_TARGET_OFFLOAD"] = "MANDATORY"
@@ -57,13 +59,17 @@
 config.substitutions.append(("%compile-and-run", "%compile && %run"))
 
 config.substitutions.append(("%compilexx",
-    "%clangxx %openmp_flags %flags %s -o %t"))
+    "%clangxx %openmp_flags %cuda_flags %flags %s -o %t"))
 config.substitutions.append(("%compile",
-    "%clang %openmp_flags %flags %s -o %t"))
+    "%clang %openmp_flags %cuda_flags %flags %s -o %t"))
 
 config.substitutions.append(("%clangxx", config.test_cxx_compiler))
 config.substitutions.append(("%clang", config.test_c_compiler))
 config.substitutions.append(("%openmp_flags", config.test_openmp_flags))
+if config.cuda_path:
+  config.substitutions.append(("%cuda_flags", "--cuda-path=" + config.cuda_path))
+else:
+  config.substitutions.append(("%cuda_flags", ""))
 config.substitutions.append(("%flags", config.test_flags))
 
 config.substitutions.append(("%run", "%t"))
diff --git a/openmp/libomptarget/deviceRTLs/nvptx/test/lit.site.cfg.in b/openmp/libomptarget/deviceRTLs/nvptx/test/lit.site.cfg.in
--- a/openmp/libomptarget/deviceRTLs/nvptx/test/lit.site.cfg.in
+++ b/openmp/libomptarget/deviceRTLs/nvptx/test/lit.site.cfg.in
@@ -4,6 +4,8 @@
 config.test_cxx_compiler = "@OPENMP_TEST_CXX_COMPILER@"
 config.test_openmp_flags = "@LIBOMPTARGET_NVPTX_TEST_OPENMP_FLAGS@"
 config.test_extra_flags = "@LIBOMPTARGET_NVPTX_TEST_FLAGS@"
+config.cuda_path = "@CUDA_TOOLKIT_ROOT_DIR@"
+config.cuda_libdir = "@CUDA_LIBDIR@"
 config.binary_dir = "@CMAKE_CURRENT_BINARY_DIR@"
 config.library_dir = "@LIBOMPTARGET_LIBRARY_DIR@"
 config.omp_header_directory = "@LIBOMPTARGET_OPENMP_HEADER_FOLDER@"
diff --git a/openmp/libomptarget/test/lit.cfg b/openmp/libomptarget/test/lit.cfg
--- a/openmp/libomptarget/test/lit.cfg
+++ b/openmp/libomptarget/test/lit.cfg
@@ -71,6 +71,8 @@
     append_dynamic_library_path('LD_LIBRARY_PATH', config.library_dir, ":")
     append_dynamic_library_path('LD_LIBRARY_PATH', \
         config.omp_host_rtl_directory, ":")
+    if config.cuda_libdir:
+        append_dynamic_library_path('LD_LIBRARY_PATH', config.cuda_libdir, ":")
     append_dynamic_library_path('LIBRARY_PATH', config.library_dir, ":")
     append_dynamic_library_path('LIBRARY_PATH', \
         config.omp_host_rtl_directory, ":")
@@ -116,9 +118,9 @@
             libomptarget_target, \
             "%not --crash %t-" + libomptarget_target))
         config.substitutions.append(("%clangxx-" + libomptarget_target, \
-            "%clangxx %openmp_flags %flags -fopenmp-targets=" + libomptarget_target))
+            "%clangxx %openmp_flags %cuda_flags %flags -fopenmp-targets=" + libomptarget_target))
         config.substitutions.append(("%clang-" + libomptarget_target, \
-            "%clang %openmp_flags %flags -fopenmp-targets=" + libomptarget_target))
+            "%clang %openmp_flags %cuda_flags %flags -fopenmp-targets=" + libomptarget_target))
         config.substitutions.append(("%fcheck-" + libomptarget_target, \
             config.libomptarget_filecheck + " %s"))
     else:
@@ -156,5 +158,9 @@
 config.substitutions.append(("%clangxx", config.test_cxx_compiler))
 config.substitutions.append(("%clang", config.test_c_compiler))
 config.substitutions.append(("%openmp_flags", config.test_openmp_flags))
+if config.cuda_path:
+  config.substitutions.append(("%cuda_flags", "--cuda-path=" + config.cuda_path))
+else:
+  config.substitutions.append(("%cuda_flags", ""))
 config.substitutions.append(("%flags", config.test_flags))
 config.substitutions.append(("%not", config.libomptarget_not))
diff --git a/openmp/libomptarget/test/lit.site.cfg.in b/openmp/libomptarget/test/lit.site.cfg.in
--- a/openmp/libomptarget/test/lit.site.cfg.in
+++ b/openmp/libomptarget/test/lit.site.cfg.in
@@ -5,6 +5,8 @@
 config.test_compiler_features = @OPENMP_TEST_COMPILER_FEATURES@
 config.test_openmp_flags = "@OPENMP_TEST_OPENMP_FLAGS@"
 config.test_extra_flags = "@OPENMP_TEST_FLAGS@"
+config.cuda_path = "@CUDA_TOOLKIT_ROOT_DIR@"
+config.cuda_libdir = "@CUDA_LIBDIR@"
 config.libomptarget_obj_root = "@CMAKE_CURRENT_BINARY_DIR@"
 config.library_dir = "@LIBOMPTARGET_LIBRARY_DIR@"
 config.omp_header_directory = "@LIBOMPTARGET_OPENMP_HEADER_FOLDER@"