diff --git a/llvm/lib/Transforms/IPO/GlobalOpt.cpp b/llvm/lib/Transforms/IPO/GlobalOpt.cpp
--- a/llvm/lib/Transforms/IPO/GlobalOpt.cpp
+++ b/llvm/lib/Transforms/IPO/GlobalOpt.cpp
@@ -1012,12 +1012,9 @@
       continue; // Otherwise, storing through it, or storing into GV... fine.
     }
 
-    // Must index into the array and into the struct.
-    if (isa<GetElementPtrInst>(Inst) && Inst->getNumOperands() >= 3) {
-      if (!ValueIsOnlyUsedLocallyOrStoredToOneGlobal(Inst, GV, PHIs))
-        return false;
-      continue;
-    }
+    // Cannot handle GEP.
+    if (isa<GetElementPtrInst>(Inst))
+      return false;
 
     if (const PHINode *PN = dyn_cast<PHINode>(Inst)) {
       // PHIs are ok if all uses are ok.  Don't infinitely recurse through PHI
diff --git a/llvm/test/Transforms/GlobalOpt/heap-sra-2-no-null-opt.ll b/llvm/test/Transforms/GlobalOpt/heap-sra-2-no-null-opt.ll
--- a/llvm/test/Transforms/GlobalOpt/heap-sra-2-no-null-opt.ll
+++ b/llvm/test/Transforms/GlobalOpt/heap-sra-2-no-null-opt.ll
@@ -9,8 +9,7 @@
 define void @bar(i32 %Size) nounwind noinline #0 {
 entry:
 	%malloccall = tail call i8* @malloc(i64 8000000) ; <i8*> [#uses=1]
-	%0 = bitcast i8* %malloccall to [1000000 x %struct.foo]* ; <[1000000 x %struct.foo]*> [#uses=1]
-	%.sub = getelementptr [1000000 x %struct.foo], [1000000 x %struct.foo]* %0, i32 0, i32 0		; <%struct.foo*> [#uses=1]
+	%.sub = bitcast i8* %malloccall to %struct.foo*
 	store %struct.foo* %.sub, %struct.foo** @X, align 4
 	ret void
 }
diff --git a/llvm/test/Transforms/GlobalOpt/heap-sra-2.ll b/llvm/test/Transforms/GlobalOpt/heap-sra-2.ll
--- a/llvm/test/Transforms/GlobalOpt/heap-sra-2.ll
+++ b/llvm/test/Transforms/GlobalOpt/heap-sra-2.ll
@@ -9,8 +9,7 @@
 define void @bar(i32 %Size) nounwind noinline {
 entry:
 	%malloccall = tail call i8* @malloc(i64 8000000) ; <i8*> [#uses=1]
-	%0 = bitcast i8* %malloccall to [1000000 x %struct.foo]* ; <[1000000 x %struct.foo]*> [#uses=1]
-	%.sub = getelementptr [1000000 x %struct.foo], [1000000 x %struct.foo]* %0, i32 0, i32 0		; <%struct.foo*> [#uses=1]
+	%.sub = bitcast i8* %malloccall to %struct.foo*
 	store %struct.foo* %.sub, %struct.foo** @X, align 4
 	ret void
 }
diff --git a/llvm/test/Transforms/GlobalOpt/heap-sra-negative.ll b/llvm/test/Transforms/GlobalOpt/heap-sra-negative.ll
new file mode 100644
--- /dev/null
+++ b/llvm/test/Transforms/GlobalOpt/heap-sra-negative.ll
@@ -0,0 +1,31 @@
+; RUN: opt < %s -S -passes=globalopt | FileCheck %s
+
+;; PR50027: Suppress SROA because we cannot represent GEP of the only storer.
+; CHECK: @X = internal unnamed_addr global %struct.foo* null
+
+target datalayout = "E-p:64:64:64-a0:0:8-f32:32:32-f64:64:64-i1:8:8-i8:8:8-i16:16:16-i32:32:32-i64:32:64-v64:64:64-v128:128:128"
+
+%struct.foo = type { i32, i32 }
+
+@X = internal global %struct.foo* null
+
+declare noalias i8* @malloc(i64)
+
+define void @test(i32 %Size) {
+entry:
+  %buf = tail call i8* @malloc(i64 8000000)
+  %buf1 = bitcast i8* %buf to [1000000 x %struct.foo]*
+
+  ;; GEP of the only storer.
+  %buf.gep = getelementptr [1000000 x %struct.foo], [1000000 x %struct.foo]* %buf1, i32 0, i32 0
+  store %struct.foo zeroinitializer, %struct.foo* %buf.gep, align 4
+
+  store %struct.foo* %buf.gep, %struct.foo** @X, align 4
+  ret void
+}
+
+define i32 @user() {
+entry:
+  %unused = load %struct.foo*, %struct.foo** @X, align 4
+  ret i32 0
+}
diff --git a/llvm/test/Transforms/GlobalOpt/heap-sra-phi-no-null-opt.ll b/llvm/test/Transforms/GlobalOpt/heap-sra-phi-no-null-opt.ll
--- a/llvm/test/Transforms/GlobalOpt/heap-sra-phi-no-null-opt.ll
+++ b/llvm/test/Transforms/GlobalOpt/heap-sra-phi-no-null-opt.ll
@@ -11,8 +11,7 @@
 ;  CHECK-LABEL: @bar(
 entry:
 	%malloccall = tail call i8* @malloc(i64 8000000) ; <i8*> [#uses=1]
-	%tmp = bitcast i8* %malloccall to [1000000 x %struct.foo]* ; <[1000000 x %struct.foo]*> [#uses=1]
-	%.sub = getelementptr [1000000 x %struct.foo], [1000000 x %struct.foo]* %tmp, i32 0, i32 0		; <%struct.foo*> [#uses=1]
+	%.sub = bitcast i8* %malloccall to %struct.foo*
 	store %struct.foo* %.sub, %struct.foo** @X, align 4
 	ret void
 }
diff --git a/llvm/test/Transforms/GlobalOpt/heap-sra-phi.ll b/llvm/test/Transforms/GlobalOpt/heap-sra-phi.ll
--- a/llvm/test/Transforms/GlobalOpt/heap-sra-phi.ll
+++ b/llvm/test/Transforms/GlobalOpt/heap-sra-phi.ll
@@ -9,8 +9,7 @@
 define void @bar(i32 %Size) nounwind noinline {
 entry:
 	%malloccall = tail call i8* @malloc(i64 8000000) ; <i8*> [#uses=1]
-	%tmp = bitcast i8* %malloccall to [1000000 x %struct.foo]* ; <[1000000 x %struct.foo]*> [#uses=1]
-	%.sub = getelementptr [1000000 x %struct.foo], [1000000 x %struct.foo]* %tmp, i32 0, i32 0		; <%struct.foo*> [#uses=1]
+	%.sub = bitcast i8* %malloccall to %struct.foo*
 	store %struct.foo* %.sub, %struct.foo** @X, align 4
 	ret void
 }