diff --git a/clang/lib/Headers/__clang_hip_cmath.h b/clang/lib/Headers/__clang_hip_cmath.h
--- a/clang/lib/Headers/__clang_hip_cmath.h
+++ b/clang/lib/Headers/__clang_hip_cmath.h
@@ -14,6 +14,7 @@
 #error "This file is for HIP and OpenMP AMDGCN device compilation only."
 #endif
 
+#if !defined(__HIPCC_RTC__)
 #if defined(__cplusplus)
 #include <limits>
 #include <type_traits>
@@ -21,6 +22,7 @@
 #endif
 #include <limits.h>
 #include <stdint.h>
+#endif // __HIPCC_RTC__
 
 #pragma push_macro("__DEVICE__")
 #define __DEVICE__ static __device__ inline __attribute__((always_inline))
diff --git a/clang/lib/Headers/__clang_hip_math.h b/clang/lib/Headers/__clang_hip_math.h
--- a/clang/lib/Headers/__clang_hip_math.h
+++ b/clang/lib/Headers/__clang_hip_math.h
@@ -13,11 +13,13 @@
 #error "This file is for HIP and OpenMP AMDGCN device compilation only."
 #endif
 
+#if !defined(__HIPCC_RTC__)
 #if defined(__cplusplus)
 #include <algorithm>
 #endif
 #include <limits.h>
 #include <stdint.h>
+#endif // __HIPCC_RTC__
 
 #pragma push_macro("__DEVICE__")
 #define __DEVICE__ static __device__ inline __attribute__((always_inline))
@@ -1260,6 +1262,7 @@
 __DEVICE__
 double min(double __x, double __y) { return fmin(__x, __y); }
 
+#if !defined(__HIPCC_RTC__)
 __host__ inline static int min(int __arg1, int __arg2) {
   return std::min(__arg1, __arg2);
 }
@@ -1267,6 +1270,7 @@
 __host__ inline static int max(int __arg1, int __arg2) {
   return std::max(__arg1, __arg2);
 }
+#endif // __HIPCC_RTC__
 #endif
 
 #pragma pop_macro("__DEVICE__")
diff --git a/clang/lib/Headers/__clang_hip_runtime_wrapper.h b/clang/lib/Headers/__clang_hip_runtime_wrapper.h
--- a/clang/lib/Headers/__clang_hip_runtime_wrapper.h
+++ b/clang/lib/Headers/__clang_hip_runtime_wrapper.h
@@ -18,9 +18,27 @@
 
 #if __HIP__
 
+#if !defined(__HIPCC_RTC__)
 #include <cmath>
 #include <cstdlib>
 #include <stdlib.h>
+#else
+typedef __SIZE_TYPE__ size_t;
+// Define macros which are needed to declare HIP device API's without standard
+// C/C++ headers. This is for readability so that these API's can be written
+// the same way as non-hipRTC use case. These macros need to be popped so that
+// they do not pollute users' name space.
+#pragma push_macro("NULL")
+#pragma push_macro("uint32_t")
+#pragma push_macro("uint64_t")
+#pragma push_macro("CHAR_BIT")
+#pragma push_macro("INT_MAX")
+#define NULL (void *)0
+#define uint32_t __UINT32_TYPE__
+#define uint64_t __UINT64_TYPE__
+#define CHAR_BIT __CHAR_BIT__
+#define INT_MAX __INTMAX_MAX__
+#endif // __HIPCC_RTC__
 
 #define __host__ __attribute__((host))
 #define __device__ __attribute__((device))
@@ -54,6 +72,7 @@
 #include <__clang_hip_libdevice_declares.h>
 #include <__clang_hip_math.h>
 
+#if !defined(__HIPCC_RTC__)
 #if !_OPENMP || __HIP_ENABLE_CUDA_WRAPPER_FOR_OPENMP__
 #include <__clang_cuda_math_forward_declares.h>
 #include <__clang_hip_cmath.h>
@@ -62,9 +81,16 @@
 #include <algorithm>
 #include <complex>
 #include <new>
+#endif // __HIPCC_RTC__
 #endif // !_OPENMP || __HIP_ENABLE_CUDA_WRAPPER_FOR_OPENMP__
 
 #define __CLANG_HIP_RUNTIME_WRAPPER_INCLUDED__ 1
-
+#if defined(__HIPCC_RTC__)
+#pragma pop_macro("NULL")
+#pragma pop_macro("uint32_t")
+#pragma pop_macro("uint64_t")
+#pragma pop_macro("CHAR_BIT")
+#pragma pop_macro("INT_MAX")
+#endif // __HIPCC_RTC__
 #endif // __HIP__
 #endif // __CLANG_HIP_RUNTIME_WRAPPER_H__
diff --git a/clang/test/Headers/hip-header.hip b/clang/test/Headers/hip-header.hip
new file mode 100644
--- /dev/null
+++ b/clang/test/Headers/hip-header.hip
@@ -0,0 +1,20 @@
+// REQUIRES: amdgpu-registered-target
+// RUN: %clang_cc1 -include __clang_hip_runtime_wrapper.h \
+// RUN:   -internal-isystem %S/../../lib/Headers/cuda_wrappers \
+// RUN:   -internal-isystem %S/Inputs/include \
+// RUN:   -triple amdgcn-amd-amdhsa -aux-triple x86_64-unknown-unknown \
+// RUN:   -target-cpu gfx906 -emit-llvm %s -fcuda-is-device -o - \
+// RUN:   -D__HIPCC_RTC__ | FileCheck %s
+
+// expected-no-diagnostics
+
+// CHECK-LABEL: amdgpu_kernel void @_Z4kernPff
+__global__ void kern(float *x, float y) {
+  *x = sin(y);
+}
+
+// CHECK-LABEL: define{{.*}} i64 @_Z11test_size_tv
+// CHEC: ret i64 8
+__device__ size_t test_size_t() {
+  return sizeof(size_t);
+}
diff --git a/clang/test/lit.cfg.py b/clang/test/lit.cfg.py
--- a/clang/test/lit.cfg.py
+++ b/clang/test/lit.cfg.py
@@ -25,7 +25,7 @@
 config.test_format = lit.formats.ShTest(not llvm_config.use_lit_shell)
 
 # suffixes: A list of file extensions to treat as test files.
-config.suffixes = ['.c', '.cpp', '.i', '.cppm', '.m', '.mm', '.cu',
+config.suffixes = ['.c', '.cpp', '.i', '.cppm', '.m', '.mm', '.cu', '.hip',
                    '.ll', '.cl', '.clcpp', '.s', '.S', '.modulemap', '.test', '.rs', '.ifs']
 
 # excludes: A list of directories to exclude from the testsuite. The 'Inputs'