diff --git a/clang/include/clang/Frontend/CompilerInstance.h b/clang/include/clang/Frontend/CompilerInstance.h
--- a/clang/include/clang/Frontend/CompilerInstance.h
+++ b/clang/include/clang/Frontend/CompilerInstance.h
@@ -377,6 +377,8 @@
   /// @name AuxTarget Info
   /// {
 
+  bool hasAuxTarget() const { return AuxTarget != nullptr; }
+
   TargetInfo *getAuxTarget() const { return AuxTarget.get(); }
 
   /// Replace the current AuxTarget.
diff --git a/clang/lib/Frontend/CompilerInstance.cpp b/clang/lib/Frontend/CompilerInstance.cpp
--- a/clang/lib/Frontend/CompilerInstance.cpp
+++ b/clang/lib/Frontend/CompilerInstance.cpp
@@ -104,8 +104,10 @@
   if (!hasTarget())
     return false;
 
-  // Create TargetInfo for the other side of CUDA/OpenMP/SYCL compilation.
-  if ((getLangOpts().CUDA || getLangOpts().OpenMPIsDevice ||
+  // Check whether AuxTarget exists, if not, then create TargetInfo for the
+  // other side of CUDA/OpenMP/SYCL compilation.
+  if (!hasAuxTarget() &&
+      (getLangOpts().CUDA || getLangOpts().OpenMPIsDevice ||
        getLangOpts().SYCLIsDevice) &&
       !getFrontendOpts().AuxTriple.empty()) {
     auto TO = std::make_shared<TargetOptions>();