diff --git a/llvm/lib/Transforms/Scalar/LoopFuse.cpp b/llvm/lib/Transforms/Scalar/LoopFuse.cpp
--- a/llvm/lib/Transforms/Scalar/LoopFuse.cpp
+++ b/llvm/lib/Transforms/Scalar/LoopFuse.cpp
@@ -99,6 +99,8 @@
 STATISTIC(NonEmptyGuardBlock, "Candidate has a non-empty guard block with "
                               "instructions that cannot be moved");
 STATISTIC(NotRotated, "Candidate is not rotated");
+STATISTIC(OnlySecondCandidateIsGuarded,
+          "The second candidate is guarded while the first one is not");
 
 enum FusionDependenceAnalysisChoice {
   FUSION_DEPENDENCE_ANALYSIS_SCEV,
@@ -891,6 +893,14 @@
             continue;
           }
 
+          if (!FC0->GuardBranch && FC1->GuardBranch) {
+            LLVM_DEBUG(dbgs() << "The second candidate is guarded while the "
+                                 "first one is not. Not fusing.\n");
+            reportLoopFusion<OptimizationRemarkMissed>(
+                *FC0, *FC1, OnlySecondCandidateIsGuarded);
+            continue;
+          }
+
           // Ensure that FC0 and FC1 have identical guards.
           // If one (or both) are not guarded, this check is not necessary.
           if (FC0->GuardBranch && FC1->GuardBranch &&
diff --git a/llvm/test/Transforms/LoopFusion/pr48060.ll b/llvm/test/Transforms/LoopFusion/pr48060.ll
new file mode 100644
--- /dev/null
+++ b/llvm/test/Transforms/LoopFusion/pr48060.ll
@@ -0,0 +1,69 @@
+; NOTE: Assertions have been autogenerated by utils/update_test_checks.py
+; RUN: opt -S -loop-fusion < %s | FileCheck %s
+; RUN: opt -S -loop-fusion -pass-remarks-output=%t < %s
+; RUN: FileCheck --input-file=%t %s --check-prefix REMARKS
+
+define dso_local void @pr48060(i1 %cond) {
+; CHECK-LABEL: @pr48060(
+; CHECK-NEXT:  entry:
+; CHECK-NEXT:    br label [[FOR_1_PH:%.*]]
+; CHECK:       for.1.ph:
+; CHECK-NEXT:    br label [[FOR_1:%.*]]
+; CHECK:       for.1:
+; CHECK-NEXT:    [[I:%.*]] = phi i32 [ 0, [[FOR_1_PH]] ], [ [[I_NEXT:%.*]], [[FOR_1]] ]
+; CHECK-NEXT:    [[I_NEXT]] = add i32 [[I]], 1
+; CHECK-NEXT:    [[COND_1:%.*]] = icmp eq i32 [[I_NEXT]], 10
+; CHECK-NEXT:    br i1 [[COND_1]], label [[FOR_1_EXIT:%.*]], label [[FOR_1]]
+; CHECK:       for.1.exit:
+; CHECK-NEXT:    br i1 [[COND:%.*]], label [[END:%.*]], label [[FOR_2_PH:%.*]]
+; CHECK:       for.2.ph:
+; CHECK-NEXT:    br label [[FOR_2:%.*]]
+; CHECK:       for.2:
+; CHECK-NEXT:    [[J:%.*]] = phi i32 [ 0, [[FOR_2_PH]] ], [ [[J_NEXT:%.*]], [[FOR_2]] ]
+; CHECK-NEXT:    [[J_NEXT]] = add i32 [[J]], 1
+; CHECK-NEXT:    [[COND_2:%.*]] = icmp eq i32 [[J_NEXT]], 10
+; CHECK-NEXT:    br i1 [[COND_2]], label [[FOR_2_EXIT:%.*]], label [[FOR_2]]
+; CHECK:       for.2.exit:
+; CHECK-NEXT:    br label [[END]]
+; CHECK:       end:
+; CHECK-NEXT:    ret void
+;
+
+; REMARKS:      --- !Missed
+; REMARKS-NEXT: Pass:            loop-fusion
+; REMARKS-NEXT: Name:            OnlySecondCandidateIsGuarded
+; REMARKS-NEXT: Function:        pr48060
+; REMARKS-NEXT: Args:
+; REMARKS:        - Cand1:           for.1.ph
+; REMARKS:        - Cand2:           for.2.ph
+; REMARKS:        - String:          The second candidate is guarded while the first one is not
+entry:
+  br label %for.1.ph
+
+for.1.ph:                                         ; preds = %entry
+  br label %for.1
+
+for.1:                                            ; preds = %for.1, %for.1.ph
+  %i = phi i32 [ 0, %for.1.ph ], [ %i.next, %for.1 ]
+  %i.next = add i32 %i, 1
+  %cond.1 = icmp eq i32 %i.next, 10
+  br i1 %cond.1, label %for.1.exit, label %for.1
+
+for.1.exit:                                       ; preds = %for.1
+  br i1 %cond, label %end, label %for.2.ph
+
+for.2.ph:                                         ; preds = %for.1.exit
+  br label %for.2
+
+for.2:                                            ; preds = %for.2, %for.2.ph
+  %j = phi i32 [ 0, %for.2.ph ], [ %j.next, %for.2 ]
+  %j.next = add i32 %j, 1
+  %cond.2 = icmp eq i32 %j.next, 10
+  br i1 %cond.2, label %for.2.exit, label %for.2
+
+for.2.exit:                                       ; preds = %for.2
+  br label %end
+
+end:                                              ; preds = %for.1.exit, %for.2.exit
+  ret void
+}