diff --git a/clang/lib/CodeGen/CodeGenModule.cpp b/clang/lib/CodeGen/CodeGenModule.cpp
--- a/clang/lib/CodeGen/CodeGenModule.cpp
+++ b/clang/lib/CodeGen/CodeGenModule.cpp
@@ -5672,6 +5672,9 @@
     // File-scope asm is ignored during device-side OpenMP compilation.
     if (LangOpts.OpenMPIsDevice)
       break;
+    // File-scope asm is ignored during device-side SYCL compilation.
+    if (LangOpts.SYCLIsDevice)
+      break;
     auto *AD = cast<FileScopeAsmDecl>(D);
     getModule().appendModuleInlineAsm(AD->getAsmString()->getString());
     break;
diff --git a/clang/test/CodeGenSYCL/filescope_asm.c b/clang/test/CodeGenSYCL/filescope_asm.c
new file mode 100644
--- /dev/null
+++ b/clang/test/CodeGenSYCL/filescope_asm.c
@@ -0,0 +1,6 @@
+// RUN:  %clang_cc1 -fsycl -fsycl-is-device -triple spir64-unknown-unknown-sycldevice -emit-llvm %s -o - | FileCheck %s
+//
+// Check that file-scope asm is ignored during device-side SYCL compilation.
+//
+// CHECK-NOT: module asm "foo"
+__asm__("foo");