diff --git a/mlir/docs/PassManagement.md b/mlir/docs/PassManagement.md
--- a/mlir/docs/PassManagement.md
+++ b/mlir/docs/PassManagement.md
@@ -1138,6 +1138,10 @@
 }
 ```
 
+The configuration dumped can be passed to `mlir-opt` by specifying
+`-run-reproducer` flag. This will result in parsing the first line configuration
+of the reproducer and adding those to the command line options.
+
 ### Local Reproducer Generation
 
 An additional flag may be passed to
diff --git a/mlir/lib/Support/MlirOptMain.cpp b/mlir/lib/Support/MlirOptMain.cpp
--- a/mlir/lib/Support/MlirOptMain.cpp
+++ b/mlir/lib/Support/MlirOptMain.cpp
@@ -29,6 +29,7 @@
 #include "llvm/Support/InitLLVM.h"
 #include "llvm/Support/Regex.h"
 #include "llvm/Support/SourceMgr.h"
+#include "llvm/Support/StringSaver.h"
 #include "llvm/Support/ToolOutputFile.h"
 
 using namespace mlir;
@@ -182,6 +183,11 @@
       "show-dialects", cl::desc("Print the list of registered dialects"),
       cl::init(false));
 
+  static cl::opt<bool> runRepro(
+      "run-reproducer",
+      cl::desc("Append the command line options of the reproducer"),
+      cl::init(false));
+
   InitLLVM y(argc, argv);
 
   // Register any command line options.
@@ -219,6 +225,23 @@
     return failure();
   }
 
+  // Parse reproducer options.
+  BumpPtrAllocator a;
+  StringSaver saver(a);
+  if (runRepro) {
+    auto pair = file->getBuffer().split('\n');
+    if (!pair.first.consume_front("// configuration:")) {
+      llvm::errs() << "Failed to find repro configuration, expect file to "
+                      "begin with '// configuration:'\n";
+      return failure();
+    }
+    // Tokenize & parse the first line.
+    SmallVector<const char *, 4> newArgv;
+    newArgv.push_back(argv[0]);
+    llvm::cl::TokenizeGNUCommandLine(pair.first, saver, newArgv);
+    cl::ParseCommandLineOptions(newArgv.size(), &newArgv[0], helpHeader);
+  }
+
   auto output = openOutputFile(outputFilename, &errorMessage);
   if (!output) {
     llvm::errs() << errorMessage << "\n";
diff --git a/mlir/test/Pass/run-reproducer.mlir b/mlir/test/Pass/run-reproducer.mlir
new file mode 100644
--- /dev/null
+++ b/mlir/test/Pass/run-reproducer.mlir
@@ -0,0 +1,22 @@
+// configuration: -mlir-disable-threading=true -pass-pipeline='func(cse,canonicalize)' -print-ir-before=cse -o /dev/null
+
+// Test of the reproducer run option. The first line has to be the
+// configuration (matching what is produced by reproducer).
+
+// RUN: mlir-opt %s -run-reproducer 2>&1 | FileCheck -check-prefix=BEFORE %s
+
+func @foo() {
+  %0 = constant 0 : i32
+  return
+}
+
+func @bar() {
+  return
+}
+
+// BEFORE: *** IR Dump Before{{.*}}CSE ***
+// BEFORE-NEXT: func @foo()
+// BEFORE: *** IR Dump Before{{.*}}CSE ***
+// BEFORE-NEXT: func @bar()
+// BEFORE-NOT: *** IR Dump Before{{.*}}Canonicalizer ***
+// BEFORE-NOT: *** IR Dump After