diff --git a/libcxx/src/CMakeLists.txt b/libcxx/src/CMakeLists.txt
--- a/libcxx/src/CMakeLists.txt
+++ b/libcxx/src/CMakeLists.txt
@@ -176,9 +176,6 @@
 # Build the shared library.
 if (LIBCXX_ENABLE_SHARED)
   add_library(cxx_shared SHARED ${exclude_from_all} ${LIBCXX_SOURCES} ${LIBCXX_HEADERS})
-  if(COMMAND llvm_setup_rpath)
-    llvm_setup_rpath(cxx_shared)
-  endif()
   target_link_libraries(cxx_shared PUBLIC cxx-headers
                                    PRIVATE ${LIBCXX_LIBRARIES})
   set_target_properties(cxx_shared
diff --git a/libcxxabi/src/CMakeLists.txt b/libcxxabi/src/CMakeLists.txt
--- a/libcxxabi/src/CMakeLists.txt
+++ b/libcxxabi/src/CMakeLists.txt
@@ -165,9 +165,6 @@
 # Build the shared library.
 if (LIBCXXABI_ENABLE_SHARED)
   add_library(cxxabi_shared SHARED ${LIBCXXABI_SOURCES} ${LIBCXXABI_HEADERS})
-  if(COMMAND llvm_setup_rpath)
-    llvm_setup_rpath(cxxabi_shared)
-  endif()
   target_link_libraries(cxxabi_shared PRIVATE ${LIBCXXABI_SHARED_LIBRARIES} ${LIBCXXABI_LIBRARIES})
   if (TARGET pstl::ParallelSTL)
     target_link_libraries(cxxabi_shared PUBLIC pstl::ParallelSTL)
diff --git a/libunwind/src/CMakeLists.txt b/libunwind/src/CMakeLists.txt
--- a/libunwind/src/CMakeLists.txt
+++ b/libunwind/src/CMakeLists.txt
@@ -125,9 +125,6 @@
   else()
     target_compile_options(unwind_shared PRIVATE -fno-rtti)
   endif()
-  if(COMMAND llvm_setup_rpath)
-    llvm_setup_rpath(unwind_shared)
-  endif()
   target_link_libraries(unwind_shared PRIVATE ${LIBUNWIND_LIBRARIES})
   set_target_properties(unwind_shared PROPERTIES
     CXX_EXTENSIONS OFF