diff --git a/clang/lib/CodeGen/CGExpr.cpp b/clang/lib/CodeGen/CGExpr.cpp
--- a/clang/lib/CodeGen/CGExpr.cpp
+++ b/clang/lib/CodeGen/CGExpr.cpp
@@ -1522,6 +1522,29 @@
   if (result.HasSideEffects)
     return ConstantEmission();
 
+  // In CUDA/HIP device compilation, a lambda may capture a reference variable
+  // referencing a global host variable by copy. In this case the lambda should
+  // make a copy of the value of the global host variable. The DRE of the
+  // captured reference variable cannot be emitted as load from the host
+  // global variable as compile time constant, since the host variable is not
+  // accessible on device. The DRE of the captured reference variable has to be
+  // loaded from captures.
+  if (CGM.getLangOpts().CUDAIsDevice &&
+      refExpr->refersToEnclosingVariableOrCapture()) {
+    auto *MD = dyn_cast_or_null<CXXMethodDecl>(CurCodeDecl);
+    if (MD && MD->getParent()->isLambda() &&
+        MD->getOverloadedOperator() == OO_Call) {
+      const APValue::LValueBase &base = result.Val.getLValueBase();
+      if (const ValueDecl *D = base.dyn_cast<const ValueDecl *>()) {
+        if (const VarDecl *VD = dyn_cast<const VarDecl>(D)) {
+          if (!VD->hasAttr<CUDADeviceAttr>()) {
+            return ConstantEmission();
+          }
+        }
+      }
+    }
+  }
+
   // Emit as a constant.
   auto C = ConstantEmitter(*this).emitAbstract(refExpr->getLocation(),
                                                result.Val, resultType);
diff --git a/clang/lib/Sema/SemaExpr.cpp b/clang/lib/Sema/SemaExpr.cpp
--- a/clang/lib/Sema/SemaExpr.cpp
+++ b/clang/lib/Sema/SemaExpr.cpp
@@ -1934,6 +1934,35 @@
                           TemplateArgs);
 }
 
+// CUDA/HIP: Check whether a captured reference variable is referencing a
+// host variable in a device or host device lambda.
+static bool isCapturingReferenceToHostVarInCUDADeviceLambda(const Sema &S,
+                                                            VarDecl *VD) {
+  if (!S.getLangOpts().CUDA || !VD->hasInit())
+    return false;
+  assert(VD->getType()->isReferenceType());
+
+  // Check whether the reference variable is referencing a host variable.
+  auto *DRE = dyn_cast<DeclRefExpr>(VD->getInit());
+  if (!DRE)
+    return false;
+  auto *Referee = dyn_cast<VarDecl>(DRE->getDecl());
+  if (!Referee || !Referee->hasGlobalStorage() ||
+      Referee->hasAttr<CUDADeviceAttr>())
+    return false;
+
+  // Check whether the current function is a device or host device lambda.
+  // Check whether the reference variable is a capture by getDeclContext()
+  // since refersToEnclosingVariableOrCapture() is not ready at this point.
+  auto *MD = dyn_cast_or_null<CXXMethodDecl>(S.CurContext);
+  if (MD && MD->getParent()->isLambda() &&
+      MD->getOverloadedOperator() == OO_Call && MD->hasAttr<CUDADeviceAttr>() &&
+      VD->getDeclContext() != MD)
+    return true;
+
+  return false;
+}
+
 NonOdrUseReason Sema::getNonOdrUseReasonInCurrentContext(ValueDecl *D) {
   // A declaration named in an unevaluated operand never constitutes an odr-use.
   if (isUnevaluatedContext())
@@ -1943,9 +1972,16 @@
   //   A variable x whose name appears as a potentially-evaluated expression e
   //   is odr-used by e unless [...] x is a reference that is usable in
   //   constant expressions.
+  // CUDA/HIP:
+  //   If a reference variable referencing a host variable is captured in a
+  //   device or host device lambda, the value of the referee must be copied
+  //   to the capture and the reference variable must be treated as odr-use
+  //   since the value of the referee is not known at compile time and must
+  //   be loaded from the captured.
   if (VarDecl *VD = dyn_cast<VarDecl>(D)) {
     if (VD->getType()->isReferenceType() &&
         !(getLangOpts().OpenMP && isOpenMPCapturedDecl(D)) &&
+        !isCapturingReferenceToHostVarInCUDADeviceLambda(*this, VD) &&
         VD->isUsableInConstantExpressions(Context))
       return NOUR_Constant;
   }
diff --git a/clang/test/CodeGenCUDA/lambda-reference-var.cu b/clang/test/CodeGenCUDA/lambda-reference-var.cu
new file mode 100644
--- /dev/null
+++ b/clang/test/CodeGenCUDA/lambda-reference-var.cu
@@ -0,0 +1,126 @@
+// RUN: %clang_cc1 -x hip -emit-llvm -std=c++11 %s -o - \
+// RUN:   -triple x86_64-linux-gnu \
+// RUN:   | FileCheck -check-prefix=HOST %s
+// RUN: %clang_cc1 -x hip -emit-llvm -std=c++11 %s -o - \
+// RUN:   -triple amdgcn-amd-amdhsa -fcuda-is-device \
+// RUN:   | FileCheck -check-prefix=DEV %s
+
+#include "Inputs/cuda.h"
+
+// HOST: %[[T1:.*]] = type <{ i32*, i32, [4 x i8] }>
+// HOST: %[[T2:.*]] = type { i32*, i32** }
+// HOST: %[[T3:.*]] = type <{ i32*, i32, [4 x i8] }>
+// DEV: %[[T1:.*]] = type { i32* }
+// DEV: %[[T2:.*]] = type { i32** }
+// DEV: %[[T3:.*]] = type <{ i32*, i32, [4 x i8] }>
+int global_host_var;
+__device__ int global_device_var;
+
+template<class F>
+__global__ void kern(F f) { f(); }
+
+// DEV-LABEL: @_ZZ27dev_capture_dev_ref_by_copyPiENKUlvE_clEv(
+// DEV: %[[VAL:.*]] = load i32, i32* addrspacecast (i32 addrspace(1)* @global_device_var to i32*)
+// DEV: store i32 %[[VAL]]
+__device__ void dev_capture_dev_ref_by_copy(int *out) {
+  int &ref = global_device_var;
+  [=](){ *out = ref;}();
+}
+
+// DEV-LABEL: @_ZZ26dev_capture_dev_ref_by_refPiENKUlvE_clEv(
+// DEV: %[[VAL:.*]] = load i32, i32* addrspacecast (i32 addrspace(1)* @global_device_var to i32*)
+// DEV: %[[VAL2:.*]] = add nsw i32 %[[VAL]], 1
+// DEV: store i32 %[[VAL2]], i32* addrspacecast (i32 addrspace(1)* @global_device_var to i32*)
+// DEV: %[[VAL:.*]] = load i32, i32* addrspacecast (i32 addrspace(1)* @global_device_var to i32*)
+// DEV: store i32 %[[VAL]]
+__device__ void dev_capture_dev_ref_by_ref(int *out) {
+  int &ref = global_device_var;
+  [&](){ ref++; *out = ref;}();
+}
+
+// DEV-LABEL: define void @_Z7dev_refPi(
+// DEV: %[[VAL:.*]] = load i32, i32* addrspacecast (i32 addrspace(1)* @global_device_var to i32*)
+// DEV: %[[VAL2:.*]] = add nsw i32 %[[VAL]], 1
+// DEV: store i32 %[[VAL2]], i32* addrspacecast (i32 addrspace(1)* @global_device_var to i32*)
+// DEV: %[[VAL:.*]] = load i32, i32* addrspacecast (i32 addrspace(1)* @global_device_var to i32*)
+// DEV: store i32 %[[VAL]]
+__device__ void dev_ref(int *out) {
+  int &ref = global_device_var;
+  ref++;
+  *out = ref;
+}
+
+// DEV-LABEL: @_ZZ14dev_lambda_refPiENKUlvE_clEv(
+// DEV: %[[VAL:.*]] = load i32, i32* addrspacecast (i32 addrspace(1)* @global_device_var to i32*)
+// DEV: %[[VAL2:.*]] = add nsw i32 %[[VAL]], 1
+// DEV: store i32 %[[VAL2]], i32* addrspacecast (i32 addrspace(1)* @global_device_var to i32*)
+// DEV: %[[VAL:.*]] = load i32, i32* addrspacecast (i32 addrspace(1)* @global_device_var to i32*)
+// DEV: store i32 %[[VAL]]
+__device__ void dev_lambda_ref(int *out) {
+  [=](){
+    int &ref = global_device_var;
+    ref++;
+    *out = ref;
+  }();
+}
+
+// HOST-LABEL: @_ZZ29host_capture_host_ref_by_copyPiENKUlvE_clEv(
+// HOST: %[[VAL:.*]] = load i32, i32* @global_host_var
+// HOST: store i32 %[[VAL]]
+void host_capture_host_ref_by_copy(int *out) {
+  int &ref = global_host_var;
+  [=](){ *out = ref;}();
+}
+
+// HOST-LABEL: @_ZZ28host_capture_host_ref_by_refPiENKUlvE_clEv(
+// HOST: %[[CAP:.*]] = getelementptr inbounds %[[T2]], %[[T2]]* %this1, i32 0, i32 0
+// HOST: %[[REF:.*]] = load i32*, i32** %[[CAP]]
+// HOST: %[[VAL:.*]] = load i32, i32* %[[REF]]
+// HOST: %[[VAL2:.*]] = add nsw i32 %[[VAL]], 1
+// HOST: store i32 %[[VAL2]], i32* %[[REF]]
+// HOST: %[[VAL:.*]] = load i32, i32* @global_host_var
+// HOST: store i32 %[[VAL]]
+void host_capture_host_ref_by_ref(int *out) {
+  int &ref = global_host_var;
+  [&](){ ref++; *out = ref;}();
+}
+
+// HOST-LABEL: define void @_Z8host_refPi(
+// HOST: %[[VAL:.*]] = load i32, i32* @global_host_var
+// HOST: %[[VAL2:.*]] = add nsw i32 %[[VAL]], 1
+// HOST: store i32 %[[VAL2]], i32* @global_host_var
+// HOST: %[[VAL:.*]] = load i32, i32* @global_host_var
+// HOST: store i32 %[[VAL]]
+void host_ref(int *out) {
+  int &ref = global_host_var;
+  ref++;
+  *out = ref;
+}
+
+// HOST-LABEL: @_ZZ15host_lambda_refPiENKUlvE_clEv(
+// HOST: %[[VAL:.*]] = load i32, i32* @global_host_var
+// HOST: %[[VAL2:.*]] = add nsw i32 %[[VAL]], 1
+// HOST: store i32 %[[VAL2]], i32* @global_host_var
+// HOST: %[[VAL:.*]] = load i32, i32* @global_host_var
+// HOST: store i32 %[[VAL]]
+void host_lambda_ref(int *out) {
+  [=](){
+    int &ref = global_host_var;
+    ref++;
+    *out = ref;
+  }();
+}
+
+// HOST-LABEL: define void @_Z28dev_capture_host_ref_by_copyPi(
+// HOST: %[[CAP:.*]] = getelementptr inbounds %[[T3]], %[[T3]]* %{{.*}}, i32 0, i32 1
+// HOST: %[[VAL:.*]] = load i32, i32* @global_host_var
+// HOST: store i32 %[[VAL]], i32* %[[CAP]]
+// DEV-LABEL: define internal void @_ZZ28dev_capture_host_ref_by_copyPiENKUlvE_clEv(
+// DEV: %[[CAP:.*]] = getelementptr inbounds %[[T3]], %[[T3]]* %this1, i32 0, i32 1
+// DEV: %[[VAL:.*]] = load i32, i32* %[[CAP]]
+// DEV: store i32 %[[VAL]]
+void dev_capture_host_ref_by_copy(int *out) {
+  int &ref = global_host_var;
+  kern<<<1, 1>>>([=]__device__() { *out = ref;});
+}
+