diff --git a/llvm/lib/Analysis/InlineCost.cpp b/llvm/lib/Analysis/InlineCost.cpp
--- a/llvm/lib/Analysis/InlineCost.cpp
+++ b/llvm/lib/Analysis/InlineCost.cpp
@@ -1101,7 +1101,7 @@
   // integer is large enough to represent the pointer.
   unsigned IntegerSize = I.getType()->getScalarSizeInBits();
   unsigned AS = I.getOperand(0)->getType()->getPointerAddressSpace();
-  if (IntegerSize >= DL.getPointerSizeInBits(AS)) {
+  if (IntegerSize == DL.getPointerSizeInBits(AS)) {
     std::pair<Value *, APInt> BaseAndOffset =
         ConstantOffsetPtrs.lookup(I.getOperand(0));
     if (BaseAndOffset.first)
diff --git a/llvm/test/Transforms/Inline/inline-ptrtoint-different-sizes.ll b/llvm/test/Transforms/Inline/inline-ptrtoint-different-sizes.ll
new file mode 100644
--- /dev/null
+++ b/llvm/test/Transforms/Inline/inline-ptrtoint-different-sizes.ll
@@ -0,0 +1,40 @@
+; RUN: opt < %s -inline -S | FileCheck %s
+
+; InlineCost used to have problems with the ptrtoint, leading to
+; crashes when visiting the trunc in pr48908_help and the icmp in
+; pr38500_help.
+
+target datalayout = "p:16:16"
+target triple = "x86_64-unknown-linux-gnu"
+
+define void @pr48980_help(i16* %p) {
+  %cast = ptrtoint i16* %p to i32
+  %sub = sub i32 %cast, %cast
+  %conv = trunc i32 %sub to i16
+  ret void
+}
+
+define void @pr48980(i16* %x) {
+  call void @pr48980_help(i16* %x)
+  ret void
+}
+
+; CHECK-LABEL: @pr48980(i16* %x)
+; CHECK-NOT:     call
+; CHECK:         ret void
+
+define void @pr38500_help(i16* %p) {
+  %cast = ptrtoint i16* %p to i32
+  %sub = sub i32 %cast, %cast
+  %cmp = icmp eq i32 %sub, 0
+  ret void
+}
+
+define void @pr38500(i16* %x) {
+  call void @pr38500_help(i16* %x)
+  ret void
+}
+
+; CHECK-LABEL: @pr38500(i16* %x)
+; CHECK-NOT:     call
+; CHECK:         ret void