diff --git a/llvm/lib/CodeGen/SplitKit.cpp b/llvm/lib/CodeGen/SplitKit.cpp
--- a/llvm/lib/CodeGen/SplitKit.cpp
+++ b/llvm/lib/CodeGen/SplitKit.cpp
@@ -663,13 +663,19 @@
         if (S.liveAt(UseIdx))
           LaneMask |= S.LaneMask;
       }
-      assert(LaneMask.any() && "Interval has no live subranges");
     } else {
       LaneMask = LaneBitmask::getAll();
     }
 
-    ++NumCopies;
-    Def = buildCopy(Edit->getReg(), Reg, LaneMask, MBB, I, Late, RegIdx);
+    if (LaneMask.none()) {
+      const MCInstrDesc &Desc = TII.get(TargetOpcode::IMPLICIT_DEF);
+      MachineInstr *ImplicitDef = BuildMI(MBB, I, DebugLoc(), Desc, Reg);
+      SlotIndexes &Indexes = *LIS.getSlotIndexes();
+      Def = Indexes.insertMachineInstrInMaps(*ImplicitDef, Late).getRegSlot();
+    } else {
+      ++NumCopies;
+      Def = buildCopy(Edit->getReg(), Reg, LaneMask, MBB, I, Late, RegIdx);
+    }
   }
 
   // Define the value in Reg.
diff --git a/llvm/test/CodeGen/AMDGPU/splitkit-nolivesubranges.mir b/llvm/test/CodeGen/AMDGPU/splitkit-nolivesubranges.mir
new file mode 100644
--- /dev/null
+++ b/llvm/test/CodeGen/AMDGPU/splitkit-nolivesubranges.mir
@@ -0,0 +1,34 @@
+# NOTE: Assertions have been autogenerated by utils/update_mir_test_checks.py
+# RUN: llc -march=amdgcn -run-pass=greedy,virtregrewriter -verify-regalloc %s | FileCheck %s
+
+---
+name: func0
+tracksRegLiveness: true
+body: |
+  bb.0:
+    liveins: $sgpr0_sgpr1
+    ; CHECK-LABEL: name: func0
+    ; CHECK: liveins: $sgpr0_sgpr1
+    ; CHECK: renamable $sgpr0 = IMPLICIT_DEF
+    ; CHECK: renamable $sgpr1 = IMPLICIT_DEF
+    ; CHECK: $sgpr104 = S_AND_B32 renamable $sgpr0, renamable $sgpr1, implicit-def $scc
+    ; CHECK: KILL implicit-def $vcc, implicit-def $sgpr0_sgpr1_sgpr2_sgpr3_sgpr4_sgpr5_sgpr6_sgpr7_sgpr8_sgpr9_sgpr10_sgpr11_sgpr12_sgpr13_sgpr14_sgpr15_sgpr16_sgpr17_sgpr18_sgpr19_sgpr20_sgpr21_sgpr22_sgpr23_sgpr24_sgpr25_sgpr26_sgpr27_sgpr28_sgpr29_sgpr30_sgpr31, implicit-def $sgpr32_sgpr33_sgpr34_sgpr35_sgpr36_sgpr37_sgpr38_sgpr39_sgpr40_sgpr41_sgpr42_sgpr43_sgpr44_sgpr45_sgpr46_sgpr47_sgpr48_sgpr49_sgpr50_sgpr51_sgpr52_sgpr53_sgpr54_sgpr55_sgpr56_sgpr57_sgpr58_sgpr59_sgpr60_sgpr61_sgpr62_sgpr63, implicit-def $sgpr64_sgpr65_sgpr66_sgpr67_sgpr68_sgpr69_sgpr70_sgpr71_sgpr72_sgpr73_sgpr74_sgpr75_sgpr76_sgpr77_sgpr78_sgpr79_sgpr80_sgpr81_sgpr82_sgpr83_sgpr84_sgpr85_sgpr86_sgpr87_sgpr88_sgpr89_sgpr90_sgpr91_sgpr92_sgpr93_sgpr94_sgpr95, implicit-def $sgpr96_sgpr97_sgpr98_sgpr99_sgpr100_sgpr101_sgpr102_sgpr103
+    ; CHECK: renamable $sgpr0_sgpr1 = IMPLICIT_DEF
+    ; CHECK: renamable $sgpr0 = IMPLICIT_DEF
+    ; CHECK: renamable $sgpr1 = IMPLICIT_DEF
+    ; CHECK: SI_SPILL_S64_SAVE renamable $sgpr0_sgpr1, %stack.0, implicit $exec, implicit $private_rsrc_reg, implicit $sp_reg :: (store 8 into %stack.0, align 4, addrspace 5)
+    ; CHECK: KILL implicit-def $vcc, implicit-def $sgpr0_sgpr1_sgpr2_sgpr3_sgpr4_sgpr5_sgpr6_sgpr7_sgpr8_sgpr9_sgpr10_sgpr11_sgpr12_sgpr13_sgpr14_sgpr15_sgpr16_sgpr17_sgpr18_sgpr19_sgpr20_sgpr21_sgpr22_sgpr23_sgpr24_sgpr25_sgpr26_sgpr27_sgpr28_sgpr29_sgpr30_sgpr31, implicit-def $sgpr32_sgpr33_sgpr34_sgpr35_sgpr36_sgpr37_sgpr38_sgpr39_sgpr40_sgpr41_sgpr42_sgpr43_sgpr44_sgpr45_sgpr46_sgpr47_sgpr48_sgpr49_sgpr50_sgpr51_sgpr52_sgpr53_sgpr54_sgpr55_sgpr56_sgpr57_sgpr58_sgpr59_sgpr60_sgpr61_sgpr62_sgpr63, implicit-def $sgpr64_sgpr65_sgpr66_sgpr67_sgpr68_sgpr69_sgpr70_sgpr71_sgpr72_sgpr73_sgpr74_sgpr75_sgpr76_sgpr77_sgpr78_sgpr79_sgpr80_sgpr81_sgpr82_sgpr83_sgpr84_sgpr85_sgpr86_sgpr87_sgpr88_sgpr89_sgpr90_sgpr91_sgpr92_sgpr93_sgpr94_sgpr95, implicit-def $sgpr96_sgpr97_sgpr98_sgpr99_sgpr100_sgpr101_sgpr102_sgpr103
+    ; CHECK: renamable $sgpr0_sgpr1 = SI_SPILL_S64_RESTORE %stack.0, implicit $exec, implicit $private_rsrc_reg, implicit $sp_reg :: (load 8 from %stack.0, align 4, addrspace 5)
+    ; CHECK: $sgpr105 = S_AND_B32 renamable $sgpr1, renamable $sgpr1, implicit-def $scc
+    ; CHECK: S_NOP 0, implicit $sgpr104, implicit $sgpr105
+    %0:sreg_64 = COPY $sgpr0_sgpr1
+    %0.sub0:sreg_64 = IMPLICIT_DEF
+    %0.sub1:sreg_64 = IMPLICIT_DEF
+    $sgpr104 = S_AND_B32 %0.sub0, %0.sub1, implicit-def $scc
+    KILL implicit-def $vcc, implicit-def $sgpr0_sgpr1_sgpr2_sgpr3_sgpr4_sgpr5_sgpr6_sgpr7_sgpr8_sgpr9_sgpr10_sgpr11_sgpr12_sgpr13_sgpr14_sgpr15_sgpr16_sgpr17_sgpr18_sgpr19_sgpr20_sgpr21_sgpr22_sgpr23_sgpr24_sgpr25_sgpr26_sgpr27_sgpr28_sgpr29_sgpr30_sgpr31, implicit-def $sgpr32_sgpr33_sgpr34_sgpr35_sgpr36_sgpr37_sgpr38_sgpr39_sgpr40_sgpr41_sgpr42_sgpr43_sgpr44_sgpr45_sgpr46_sgpr47_sgpr48_sgpr49_sgpr50_sgpr51_sgpr52_sgpr53_sgpr54_sgpr55_sgpr56_sgpr57_sgpr58_sgpr59_sgpr60_sgpr61_sgpr62_sgpr63, implicit-def $sgpr64_sgpr65_sgpr66_sgpr67_sgpr68_sgpr69_sgpr70_sgpr71_sgpr72_sgpr73_sgpr74_sgpr75_sgpr76_sgpr77_sgpr78_sgpr79_sgpr80_sgpr81_sgpr82_sgpr83_sgpr84_sgpr85_sgpr86_sgpr87_sgpr88_sgpr89_sgpr90_sgpr91_sgpr92_sgpr93_sgpr94_sgpr95, implicit-def $sgpr96_sgpr97_sgpr98_sgpr99_sgpr100_sgpr101_sgpr102_sgpr103
+    %0.sub0:sreg_64 = IMPLICIT_DEF
+    %0.sub1:sreg_64 = IMPLICIT_DEF
+    KILL implicit-def $vcc, implicit-def $sgpr0_sgpr1_sgpr2_sgpr3_sgpr4_sgpr5_sgpr6_sgpr7_sgpr8_sgpr9_sgpr10_sgpr11_sgpr12_sgpr13_sgpr14_sgpr15_sgpr16_sgpr17_sgpr18_sgpr19_sgpr20_sgpr21_sgpr22_sgpr23_sgpr24_sgpr25_sgpr26_sgpr27_sgpr28_sgpr29_sgpr30_sgpr31, implicit-def $sgpr32_sgpr33_sgpr34_sgpr35_sgpr36_sgpr37_sgpr38_sgpr39_sgpr40_sgpr41_sgpr42_sgpr43_sgpr44_sgpr45_sgpr46_sgpr47_sgpr48_sgpr49_sgpr50_sgpr51_sgpr52_sgpr53_sgpr54_sgpr55_sgpr56_sgpr57_sgpr58_sgpr59_sgpr60_sgpr61_sgpr62_sgpr63, implicit-def $sgpr64_sgpr65_sgpr66_sgpr67_sgpr68_sgpr69_sgpr70_sgpr71_sgpr72_sgpr73_sgpr74_sgpr75_sgpr76_sgpr77_sgpr78_sgpr79_sgpr80_sgpr81_sgpr82_sgpr83_sgpr84_sgpr85_sgpr86_sgpr87_sgpr88_sgpr89_sgpr90_sgpr91_sgpr92_sgpr93_sgpr94_sgpr95, implicit-def $sgpr96_sgpr97_sgpr98_sgpr99_sgpr100_sgpr101_sgpr102_sgpr103
+    $sgpr105 = S_AND_B32 %0.sub1, %0.sub1, implicit-def $scc
+    S_NOP 0, implicit $sgpr104, implicit $sgpr105
+...