diff --git a/llvm/lib/Transforms/IPO/OpenMPOpt.cpp b/llvm/lib/Transforms/IPO/OpenMPOpt.cpp
--- a/llvm/lib/Transforms/IPO/OpenMPOpt.cpp
+++ b/llvm/lib/Transforms/IPO/OpenMPOpt.cpp
@@ -1480,6 +1480,9 @@
     auto &SetterRFI = OMPInfoCache.RFIs[OMPInfoCache.ICVs[ICV].Setter];
     Function *CalledFunction = CB->getCalledFunction();
 
+    // Indirect call, assume ICV changes.
+    if (CalledFunction == nullptr)
+      return nullptr;
     if (CalledFunction == GetterRFI.Declaration)
       return None;
     if (CalledFunction == SetterRFI.Declaration) {
diff --git a/llvm/test/Transforms/OpenMP/icv_tracking.ll b/llvm/test/Transforms/OpenMP/icv_tracking.ll
--- a/llvm/test/Transforms/OpenMP/icv_tracking.ll
+++ b/llvm/test/Transforms/OpenMP/icv_tracking.ll
@@ -30,6 +30,21 @@
   ret i32 %2
 }
 
+define void @indirect_call(void ()* %0) {
+; CHECK-LABEL: define {{[^@]+}}@indirect_call
+; CHECK-SAME: (void ()* [[TMP0:%.*]])
+; CHECK-NEXT:    call void @omp_set_num_threads(i32 4)
+; CHECK-NEXT:    tail call void [[TMP0]]()
+; CHECK-NEXT:    [[TMP2:%.*]] = tail call i32 @omp_get_max_threads()
+; CHECK-NEXT:    tail call void @use(i32 [[TMP2]])
+; CHECK-NEXT:    ret void
+  call void @omp_set_num_threads(i32 4)
+  tail call void %0()
+  %2 = tail call i32 @omp_get_max_threads()
+  tail call void @use(i32 %2)
+  ret void
+}
+
 define dso_local i32 @foo(i32 %0, i32 %1) {
 ; CHECK-LABEL: define {{[^@]+}}@foo
 ; CHECK-SAME: (i32 [[TMP0:%.*]], i32 [[TMP1:%.*]])