diff --git a/llvm/lib/Transforms/Instrumentation/MemorySanitizer.cpp b/llvm/lib/Transforms/Instrumentation/MemorySanitizer.cpp
--- a/llvm/lib/Transforms/Instrumentation/MemorySanitizer.cpp
+++ b/llvm/lib/Transforms/Instrumentation/MemorySanitizer.cpp
@@ -3551,6 +3551,12 @@
       maybeMarkSanitizerLibraryCallNoBuiltin(Call, TLI);
     }
     IRBuilder<> IRB(&CB);
+    bool MayCheckCall = ClEagerChecks;
+    if (Function *Func = CB.getCalledFunction()) {
+      // __sanitizer_unaligned_{load,store} functions may be called by users
+      // and always expects shadows in the TLS. So don't check them.
+      MayCheckCall &= !Func->getName().startswith("__sanitizer_unaligned_");
+    }
 
     unsigned ArgOffset = 0;
     LLVM_DEBUG(dbgs() << "  CallSite: " << CB << "\n");
@@ -3576,7 +3582,7 @@
 
       bool ByVal = CB.paramHasAttr(i, Attribute::ByVal);
       bool NoUndef = CB.paramHasAttr(i, Attribute::NoUndef);
-      bool EagerCheck = ClEagerChecks && !ByVal && NoUndef;
+      bool EagerCheck = MayCheckCall && !ByVal && NoUndef;
 
       if (EagerCheck) {
         insertShadowCheck(A, &CB);
@@ -3632,7 +3638,7 @@
     if (isa<CallInst>(CB) && cast<CallInst>(CB).isMustTailCall())
       return;
 
-    if (ClEagerChecks && CB.hasRetAttr(Attribute::NoUndef)) {
+    if (MayCheckCall && CB.hasRetAttr(Attribute::NoUndef)) {
       setShadow(&CB, getCleanShadow(&CB));
       setOrigin(&CB, getCleanOrigin());
       return;
diff --git a/llvm/test/Instrumentation/MemorySanitizer/no-check-rt-unaligned.ll b/llvm/test/Instrumentation/MemorySanitizer/no-check-rt-unaligned.ll
new file mode 100644
--- /dev/null
+++ b/llvm/test/Instrumentation/MemorySanitizer/no-check-rt-unaligned.ll
@@ -0,0 +1,30 @@
+; RUN: opt < %s -msan-eager-checks -msan-check-access-address=0 -S -passes=msan 2>&1 | FileCheck %s
+; RUN: opt < %s -msan-eager-checks -msan-check-access-address=0 -msan-track-origins=2 -S -passes=msan 2>&1 | FileCheck %s -check-prefixes=CHECK,CHECK-ORIGIN
+; RUN: opt < %s -msan-eager-checks -msan -msan-check-access-address=0 -S | FileCheck %s
+target datalayout = "e-p:64:64:64-i1:8:8-i8:8:8-i16:16:16-i32:32:32-i64:64:64-f32:32:32-f64:64:64-v64:64:64-v128:128:128-a0:0:64-s0:64:64-f80:128:128-n8:16:32:64-S128"
+target triple = "x86_64-unknown-linux-gnu"
+
+declare noundef i8 @__sanitizer_unaligned_load8(i8* noundef)
+declare void @__sanitizer_unaligned_store8(i8* noundef, i8 noundef)
+
+define noundef i8 @unaligned_load(i8* noundef %ptr) sanitize_memory {
+; CHECK: @unaligned_load(i8* {{.*}}[[PTR:%.+]])
+; CHECK: store i64 0, {{.*}} @__msan_param_tls
+; CHECK: [[VAL:%.*]] = call noundef i8 @__sanitizer_unaligned_load8(i8* noundef [[PTR]])
+  %val = call noundef i8 @__sanitizer_unaligned_load8(i8* noundef %ptr)
+; CHECK: load {{.*}} @__msan_retval_tls
+; CHECK-ORIGIN: load {{.*}} @__msan_retval_origin_tls
+; CHECK: call void @__msan_warning_{{.*}}noreturn
+; CHECK: ret i8 [[VAL]]
+  ret i8 %val
+}
+
+define void @unaligned_store(i8* noundef %ptr, i8 noundef %val) sanitize_memory {
+; CHECK: @unaligned_store(i8* {{.*}}[[PTR:%.+]], i8 {{.*}}[[VAL:%.+]])
+; CHECK: store i64 0, {{.*}} @__msan_param_tls
+; CHECK: store i8 0, {{.*}} @__msan_param_tls
+; CHECK: call void @__sanitizer_unaligned_store8(i8* noundef [[PTR]], i8 noundef [[VAL]])
+  call void @__sanitizer_unaligned_store8(i8* noundef %ptr, i8 noundef %val)
+; CHECK: ret void
+  ret void
+}