diff --git a/llvm/lib/Transforms/Instrumentation/MemorySanitizer.cpp b/llvm/lib/Transforms/Instrumentation/MemorySanitizer.cpp
--- a/llvm/lib/Transforms/Instrumentation/MemorySanitizer.cpp
+++ b/llvm/lib/Transforms/Instrumentation/MemorySanitizer.cpp
@@ -3046,6 +3046,32 @@
     SOC.Done(&I);
   }
 
+  // Instrument _mm_*_sd intrinsics
+  void handleUnarySdIntrinsic(IntrinsicInst &I) {
+    IRBuilder<> IRB(&I);
+    Value *First = getShadow(&I, 0);
+    Value *Second = getShadow(&I, 1);
+    // High word of first operand, low word of second
+    Value *Shadow =
+        IRB.CreateShuffleVector(First, Second, llvm::makeArrayRef<int>({2, 1}));
+
+    setShadow(&I, Shadow);
+    setOriginForNaryOp(I);
+  }
+
+  void handleBinarySdIntrinsic(IntrinsicInst &I) {
+    IRBuilder<> IRB(&I);
+    Value *First = getShadow(&I, 0);
+    Value *Second = getShadow(&I, 1);
+    Value *OrShadow = IRB.CreateOr(First, Second);
+    // High word of first operand, low word of both OR'd together
+    Value *Shadow = IRB.CreateShuffleVector(First, OrShadow,
+                                            llvm::makeArrayRef<int>({2, 1}));
+
+    setShadow(&I, Shadow);
+    setOriginForNaryOp(I);
+  }
+
   void visitIntrinsicInst(IntrinsicInst &I) {
     switch (I.getIntrinsicID()) {
     case Intrinsic::lifetime_start:
@@ -3285,6 +3311,14 @@
       handlePclmulIntrinsic(I);
       break;
 
+    case Intrinsic::x86_sse41_round_sd:
+      handleUnarySdIntrinsic(I);
+      break;
+    case Intrinsic::x86_sse2_max_sd:
+    case Intrinsic::x86_sse2_min_sd:
+      handleBinarySdIntrinsic(I);
+      break;
+
     case Intrinsic::is_constant:
       // The result of llvm.is.constant() is always defined.
       setShadow(&I, getCleanShadow(&I));