diff --git a/llvm/lib/Target/AMDGPU/SIRegisterInfo.cpp b/llvm/lib/Target/AMDGPU/SIRegisterInfo.cpp
--- a/llvm/lib/Target/AMDGPU/SIRegisterInfo.cpp
+++ b/llvm/lib/Target/AMDGPU/SIRegisterInfo.cpp
@@ -327,6 +327,12 @@
     // Reserve 4 SGPRs for the scratch buffer resource descriptor in case we need
     // to spill.
     // TODO: May need to reserve a VGPR if doing LDS spilling.
+    const MachineRegisterInfo &MRI = MF.getRegInfo();
+    for (unsigned i = 0; i < 4; ++i) {
+      Register SubReg = getSubReg(ScratchRSrcReg, getSubRegFromChannel(i));
+      if (MRI.isLiveIn(SubReg))
+        report_fatal_error("scratch resource registers overlap live in");
+    }
     reserveRegisterTuples(Reserved, ScratchRSrcReg);
   }
 
@@ -336,20 +342,23 @@
   MCRegister StackPtrReg = MFI->getStackPtrOffsetReg();
 
   if (StackPtrReg) {
+    if (isSubRegister(ScratchRSrcReg, StackPtrReg))
+      report_fatal_error("scratch resource registers overlap stack pointer");
     reserveRegisterTuples(Reserved, StackPtrReg);
-    assert(!isSubRegister(ScratchRSrcReg, StackPtrReg));
   }
 
   MCRegister FrameReg = MFI->getFrameOffsetReg();
   if (FrameReg) {
+    if (isSubRegister(ScratchRSrcReg, FrameReg))
+      report_fatal_error("scratch resource registers overlap frame offset");
     reserveRegisterTuples(Reserved, FrameReg);
-    assert(!isSubRegister(ScratchRSrcReg, FrameReg));
   }
 
   if (hasBasePointer(MF)) {
     MCRegister BasePtrReg = getBaseRegister();
+    if (isSubRegister(ScratchRSrcReg, BasePtrReg))
+      report_fatal_error("scratch resource registers overlap base pointer");
     reserveRegisterTuples(Reserved, BasePtrReg);
-    assert(!isSubRegister(ScratchRSrcReg, BasePtrReg));
   }
 
   for (MCRegister Reg : MFI->WWMReservedRegs) {