diff --git a/llvm/lib/Target/AMDGPU/SIRegisterInfo.cpp b/llvm/lib/Target/AMDGPU/SIRegisterInfo.cpp
--- a/llvm/lib/Target/AMDGPU/SIRegisterInfo.cpp
+++ b/llvm/lib/Target/AMDGPU/SIRegisterInfo.cpp
@@ -336,20 +336,23 @@
   MCRegister StackPtrReg = MFI->getStackPtrOffsetReg();
 
   if (StackPtrReg) {
+    if (isSubRegister(ScratchRSrcReg, StackPtrReg))
+      report_fatal_error("scratch resource registers overlap stack pointer");
     reserveRegisterTuples(Reserved, StackPtrReg);
-    assert(!isSubRegister(ScratchRSrcReg, StackPtrReg));
   }
 
   MCRegister FrameReg = MFI->getFrameOffsetReg();
   if (FrameReg) {
+    if (isSubRegister(ScratchRSrcReg, FrameReg))
+      report_fatal_error("scratch resource registers overlap frame offset");
     reserveRegisterTuples(Reserved, FrameReg);
-    assert(!isSubRegister(ScratchRSrcReg, FrameReg));
   }
 
   if (hasBasePointer(MF)) {
     MCRegister BasePtrReg = getBaseRegister();
+    if (isSubRegister(ScratchRSrcReg, BasePtrReg))
+      report_fatal_error("scratch resource registers overlap base pointer");
     reserveRegisterTuples(Reserved, BasePtrReg);
-    assert(!isSubRegister(ScratchRSrcReg, BasePtrReg));
   }
 
   for (MCRegister Reg : MFI->WWMReservedRegs) {