diff --git a/clang/lib/Basic/Targets.cpp b/clang/lib/Basic/Targets.cpp
--- a/clang/lib/Basic/Targets.cpp
+++ b/clang/lib/Basic/Targets.cpp
@@ -117,6 +117,9 @@
     return new XCoreTargetInfo(Triple, Opts);
 
   case llvm::Triple::hexagon:
+    if (os == llvm::Triple::Linux &&
+        Triple.getEnvironment() == llvm::Triple::Musl)
+      return new LinuxTargetInfo<HexagonTargetInfo>(Triple, Opts);
     return new HexagonTargetInfo(Triple, Opts);
 
   case llvm::Triple::lanai:
diff --git a/clang/test/Preprocessor/hexagon-predefines.c b/clang/test/Preprocessor/hexagon-predefines.c
--- a/clang/test/Preprocessor/hexagon-predefines.c
+++ b/clang/test/Preprocessor/hexagon-predefines.c
@@ -101,3 +101,15 @@
 // RUN: -target-feature +hvxv67 -target-feature +hvx-length128b %s | FileCheck \
 // RUN: %s -check-prefix CHECK-ELF
 // CHECK-ELF: #define __ELF__ 1
+
+// RUN: %clang_cc1 -E -dM -triple hexagon-unknown-linux-musl \
+// RUN: -target-cpu hexagonv67 -target-feature +hvxv67 \
+// RUN: -target-feature +hvx-length128b %s | FileCheck \
+// RUN: %s -check-prefix CHECK-LINUX
+// CHECK-LINUX: #define __gnu_linux__ 1
+// CHECK-LINUX: #define __linux 1
+// CHECK-LINUX: #define __linux__ 1
+// CHECK-LINUX: #define __unix 1
+// CHECK-LINUX: #define __unix__ 1
+// CHECK-LINUX: #define linux 1
+// CHECK-LINUX: #define unix 1