diff --git a/clang/lib/Format/TokenAnnotator.cpp b/clang/lib/Format/TokenAnnotator.cpp
--- a/clang/lib/Format/TokenAnnotator.cpp
+++ b/clang/lib/Format/TokenAnnotator.cpp
@@ -2900,9 +2900,19 @@
       return false;
     return true;
   }
-  if (Left.is(TT_UnaryOperator))
+  if (Left.is(TT_UnaryOperator)) {
+    // The alternative operators for ~ and ! are "compl" and "not".
+    // If they are used instead, we do not want to combine them with
+    // the token to the right, unless that is a left paren.
+    if (!Right.is(tok::l_paren)) {
+      if (Left.is(tok::exclaim) && Left.TokenText == "not")
+        return true;
+      if (Left.is(tok::tilde) && Left.TokenText == "compl")
+        return true;
+    }
     return (Style.SpaceAfterLogicalNot && Left.is(tok::exclaim)) ||
            Right.is(TT_BinaryOperator);
+  }
 
   // If the next token is a binary operator or a selector name, we have
   // incorrectly classified the parenthesis as a cast. FIXME: Detect correctly.
diff --git a/clang/unittests/Format/FormatTest.cpp b/clang/unittests/Format/FormatTest.cpp
--- a/clang/unittests/Format/FormatTest.cpp
+++ b/clang/unittests/Format/FormatTest.cpp
@@ -14609,6 +14609,48 @@
   verifyFormat("auto lambda = [&a = a]() { a = 2; };", AlignStyle);
 }
 
+TEST_F(FormatTest, AlternativeOperators) {
+  // Test case for ensuring alternate operators are not
+  // combined with their right most neighbour.
+  verifyFormat("int a and b;");
+  verifyFormat("int a and_eq b;");
+  verifyFormat("int a bitand b;");
+  verifyFormat("int a bitor b;");
+  verifyFormat("int a compl b;");
+  verifyFormat("int a not b;");
+  verifyFormat("int a not_eq b;");
+  verifyFormat("int a or b;");
+  verifyFormat("int a xor b;");
+  verifyFormat("int a xor_eq b;");
+  verifyFormat("return this not_eq bitand other;");
+  verifyFormat("bool operator not_eq(const X bitand other)");
+
+  verifyFormat("int a and 5;");
+  verifyFormat("int a and_eq 5;");
+  verifyFormat("int a bitand 5;");
+  verifyFormat("int a bitor 5;");
+  verifyFormat("int a compl 5;");
+  verifyFormat("int a not 5;");
+  verifyFormat("int a not_eq 5;");
+  verifyFormat("int a or 5;");
+  verifyFormat("int a xor 5;");
+  verifyFormat("int a xor_eq 5;");
+
+  verifyFormat("int a compl(5);");
+  verifyFormat("int a not(5);");
+
+  /* FIXME handle alternate tokens
+   * https://en.cppreference.com/w/cpp/language/operator_alternative
+  // alternative tokens
+  verifyFormat("compl foo();");     //  ~foo();
+  verifyFormat("foo() <%%>;");      // foo();
+  verifyFormat("void foo() <%%>;"); // void foo(){}
+  verifyFormat("int a <:1:>;");     // int a[1];[
+  verifyFormat("%:define ABC abc"); // #define ABC abc
+  verifyFormat("%:%:");             // ##
+  */
+}
+
 } // end namespace
 } // end namespace format
 } // end namespace clang