Index: lldb/source/Plugins/ScriptInterpreter/Python/ScriptInterpreterPython.cpp
===================================================================
--- lldb/source/Plugins/ScriptInterpreter/Python/ScriptInterpreterPython.cpp
+++ lldb/source/Plugins/ScriptInterpreter/Python/ScriptInterpreterPython.cpp
@@ -176,6 +176,16 @@
     static char g_python_home[] = LLDB_PYTHON_HOME;
 #endif
     Py_SetPythonHome(g_python_home);
+#endif
+#else
+#if defined(__APPLE__) && PY_MAJOR_VERSION == 2 && PY_MINOR_VERSION == 7
+    // For Darwin, the only Python version supported is the one shipped in the OS
+    // and linked with lldb. Other installation of Python may have higher priorities
+    // in the path, overriding PYTHONHOME and causing problems/incompatibilities.
+    // In order to avoid confusion, always hardcode the PythonHome to be right,
+    // as it's not going to change.
+    Py_SetPythonHome("/System/Library/Frameworks/Python.framework/Versions/2.7");
+#endif
 #endif
   }