diff --git a/llvm/cmake/modules/HandleLLVMOptions.cmake b/llvm/cmake/modules/HandleLLVMOptions.cmake
--- a/llvm/cmake/modules/HandleLLVMOptions.cmake
+++ b/llvm/cmake/modules/HandleLLVMOptions.cmake
@@ -236,7 +236,7 @@
 
 # Pass -Wl,-z,defs. This makes sure all symbols are defined. Otherwise a DSO
 # build might work on ELF but fail on MachO/COFF.
-if(NOT (CMAKE_SYSTEM_NAME MATCHES "Darwin|FreeBSD|OpenBSD|DragonFly|AIX|OS390" OR
+if(NOT (CMAKE_SYSTEM_NAME MATCHES "Darwin|FreeBSD|OpenBSD|DragonFly|AIX|OS390|SerenityOS" OR
         WIN32 OR CYGWIN) AND
    NOT LLVM_USE_SANITIZER)
   set(CMAKE_SHARED_LINKER_FLAGS "${CMAKE_SHARED_LINKER_FLAGS} -Wl,-z,defs")