diff --git a/clang/lib/Driver/ToolChains/Clang.cpp b/clang/lib/Driver/ToolChains/Clang.cpp
--- a/clang/lib/Driver/ToolChains/Clang.cpp
+++ b/clang/lib/Driver/ToolChains/Clang.cpp
@@ -801,6 +801,20 @@
     PGOGenerateArg = nullptr;
   }
 
+  if (TC.getTriple().isOSAIX()) {
+    if (PGOGenerateArg)
+      if (!D.isUsingLTO(false /*IsDeviceOffloadAction */) ||
+          D.getLTOMode() != LTOK_Full)
+        D.Diag(clang::diag::err_drv_argument_only_allowed_with)
+            << PGOGenerateArg->getSpelling() << "-flto";
+    if (ProfileGenerateArg)
+      D.Diag(diag::err_drv_unsupported_opt_for_target)
+          << ProfileGenerateArg->getSpelling() << TC.getTriple().str();
+    if (Arg *ProfileSampleUseArg = getLastProfileSampleUseArg(Args))
+      D.Diag(diag::err_drv_unsupported_opt_for_target)
+          << ProfileSampleUseArg->getSpelling() << TC.getTriple().str();
+  }
+
   if (ProfileGenerateArg) {
     if (ProfileGenerateArg->getOption().matches(
             options::OPT_fprofile_instr_generate_EQ))
diff --git a/clang/test/Driver/unsupported-option.c b/clang/test/Driver/unsupported-option.c
--- a/clang/test/Driver/unsupported-option.c
+++ b/clang/test/Driver/unsupported-option.c
@@ -1,7 +1,23 @@
 // RUN: not %clang %s --hedonism -### 2>&1 | \
 // RUN: FileCheck %s
+// CHECK: error: unsupported option '--hedonism'
+
 // RUN: not %clang %s --hell -### 2>&1 | \
 // RUN: FileCheck %s --check-prefix=DID-YOU-MEAN
-
-// CHECK: error: unsupported option '--hedonism'
 // DID-YOU-MEAN: error: unsupported option '--hell'; did you mean '--help'?
+
+// RUN: not %clang -fprofile-instr-generate --target=powerpc-ibm-aix %s 2>&1 | \
+// RUN: FileCheck %s --check-prefix=INVALID-AIX-PROFILE
+// INVALID-AIX-PROFILE: error: unsupported option '-fprofile-instr-generate' for target
+
+// RUN: not %clang -fprofile-sample-use=code.prof --target=powerpc-ibm-aix %s 2>&1 | \
+// RUN: FileCheck %s --check-prefix=AIX-PROFILE-SAMPLE
+// AIX-PROFILE-SAMPLE: error: unsupported option '-fprofile-sample-use=' for target
+
+// RUN: not %clang -fprofile-generate --target=powerpc-ibm-aix %s 2>&1 | \
+// RUN: FileCheck %s --check-prefix=AIX-PROFILE-LTO
+// AIX-PROFILE-LTO: error: invalid argument '-fprofile-generate' only allowed with '-flto'
+
+// RUN: not %clang -fprofile-generate -flto=thin --target=powerpc64-ibm-aix %s 2>&1 | \
+// RUN: FileCheck %s --check-prefix=AIX-PROFILE-THINLTO
+// AIX-PROFILE-THINLTO: error: invalid argument '-fprofile-generate' only allowed with '-flto'