diff --git a/lldb/source/Target/TargetList.cpp b/lldb/source/Target/TargetList.cpp
--- a/lldb/source/Target/TargetList.cpp
+++ b/lldb/source/Target/TargetList.cpp
@@ -48,6 +48,7 @@
                                 LoadDependentFiles load_dependent_files,
                                 const OptionGroupPlatform *platform_options,
                                 TargetSP &target_sp) {
+  std::lock_guard<std::recursive_mutex> guard(m_target_list_mutex);
   auto result = TargetList::CreateTargetInternal(
       debugger, user_exe_path, triple_str, load_dependent_files,
       platform_options, target_sp);
@@ -62,6 +63,7 @@
                                 const ArchSpec &specified_arch,
                                 LoadDependentFiles load_dependent_files,
                                 PlatformSP &platform_sp, TargetSP &target_sp) {
+  std::lock_guard<std::recursive_mutex> guard(m_target_list_mutex);
   auto result = TargetList::CreateTargetInternal(
       debugger, user_exe_path, specified_arch, load_dependent_files,
       platform_sp, target_sp);