diff --git a/compiler-rt/test/asan/lit.cfg.py b/compiler-rt/test/asan/lit.cfg.py
--- a/compiler-rt/test/asan/lit.cfg.py
+++ b/compiler-rt/test/asan/lit.cfg.py
@@ -53,6 +53,41 @@
       (new_path, config.environment.get(dynamic_library_lookup_var, '')))
     config.environment[dynamic_library_lookup_var] = new_ld_library_path_64
 
+def find_clang_compiler_rt_libdir(config):
+  import subprocess
+  clang_cmd = [
+    config.clang.strip(),
+    '-print-file-name=lib',
+  ]
+  try:
+    result = subprocess.run(
+      clang_cmd,
+      stdout=subprocess.PIPE,
+      stderr=subprocess.PIPE,
+      check=True
+    )
+  except subprocess.CalledProcessError as e:
+    msg = 'Failed to run {}\nrc:{}\nstdout:{}\nstderr:{}\n'.format(
+        clang_cmd,
+        e.returncode,
+        e.stdout,
+        e.stderr)
+    lit_config.fatal(msg)
+  path = result.stdout.decode().strip()
+  if not os.path.exists(path):
+    lit_config.fatal('Path reported by clang does not exist: {}'.format(path))
+  path = os.path.realpath(path)
+  if config.host_os == 'Darwin':
+    path = os.path.join(path, 'darwin')
+
+  config_crt_libdir_real = os.path.realpath(config.compiler_rt_libdir)
+  if path != config_crt_libdir_real:
+    # Note it's possible for this mismatch to occur when doing a
+    # Standalone build of compiler-rt.
+    lit_config.warning('Path reported by clang ({}) != configured path ({})'.format(
+      path, config_crt_libdir_real))
+  return path
+
 # Setup config name.
 config.name = 'AddressSanitizer' + config.name_suffix
 
@@ -134,7 +169,9 @@
   if config.host_os in ['Linux', 'FreeBSD', 'NetBSD', 'SunOS']:
     shared_libasan_path = os.path.join(config.compiler_rt_libdir, "libclang_rt.asan{}.so".format(config.target_suffix))
   elif config.host_os == 'Darwin':
-    shared_libasan_path = os.path.join(config.compiler_rt_libdir, 'libclang_rt.asan_{}_dynamic.dylib'.format(config.apple_platform))
+    shared_libasan_path = os.path.join(
+      find_clang_compiler_rt_libdir(config),
+      'libclang_rt.asan_{}_dynamic.dylib'.format(config.apple_platform))
   else:
     lit_config.warning('%shared_libasan substitution not set but dynamic ASan is available.')
     shared_libasan_path = None